Eon Kuek Li, Leffler Melanie, Mackay Graham A, Hulett Mark D
Department of Pharmacology and Therapeutics, and Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia.
John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Immunol Cell Biol. 2016 Jan;94(1):11-23. doi: 10.1038/icb.2015.48. Epub 2015 Apr 3.
The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in regulating cell activation, growth and development. However, beyond MS4A1-3 there are a large number of related molecules (18 to date in humans) where our understanding of their biological roles is at a relatively nascent stage. This review examines the larger MS4A family focusing on their structure, expression, regulation and characterized and/or emerging biological roles. Our own work on one family member MS4A8B, and its possible role in epithelial cell regulation, is also highlighted.
MS4A（跨膜4结构域家族，A亚家族）蛋白家族包含一些知名成员，包括MS4A1（CD20）、MS4A2（FcɛRIβ）和MS4A3（HTm4）。这三个MS4A家族成员在特定白细胞亚群的细胞表面表达，并且已被充分表征为在调节细胞激活、生长和发育中起关键作用。然而，除了MS4A1 - 3之外，还有大量相关分子（目前人类中有18种），我们对它们生物学作用的了解尚处于相对初期阶段。本综述考察了更大的MS4A家族，重点关注其结构、表达、调控以及已明确的和/或新出现的生物学作用。我们自己关于一个家族成员MS4A8B及其在上皮细胞调节中可能作用的研究也将被重点介绍。
