Materniak Magdalena, Kubiś Piotr, Rola-Łuszczak Marzena, Khan Arifa S, Buseyne Florence, Lindemann Dirk, Löchelt Martin, Kuźmak Jacek
Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Laboratory of Retroviruses, Division of Viral Products, OVRR, CBER, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
Viruses. 2015 Mar 31;7(4):1651-66. doi: 10.3390/v7041651.
For the past two decades, scientists from around the world, working on different aspects of foamy virus (FV) research, have gathered in different research institutions almost every two years to present their recent results in formal talks, to discuss their ongoing studies informally, and to initiate fruitful collaborations. In this report we review the 2014 anniversary conference to share the meeting summary with the virology community and hope to arouse interest by other researchers to join this exciting field. The topics covered included epidemiology, virus molecular biology, and immunology of FV infection in non-human primates, cattle, and humans with zoonotic FV infections, as well as recent findings on endogenous FVs. Several topics focused on virus replication and interactions between viral and cellular proteins. Use of FV in biomedical research was highlighted with presentations on using FV vectors for gene therapy and FV proteins as scaffold for vaccine antigen presentation. On behalf of the FV community, this report also includes a short tribute to commemorate Prof. Axel Rethwilm, one of the leading experts in the field of retrovirology and foamy viruses, who passed away 29 July 2014.
在过去的二十年里，来自世界各地致力于泡沫病毒（FV）研究不同方面的科学家们，几乎每两年就会齐聚不同的研究机构，通过正式演讲展示他们的最新研究成果，进行非正式的研究讨论，并开展卓有成效的合作。在本报告中，我们回顾了2014年的周年会议，与病毒学界分享会议总结，希望能激发其他研究人员对这个令人兴奋的领域产生兴趣。涵盖的主题包括非人灵长类动物、牛以及感染人畜共患FV的人类中FV感染的流行病学、病毒分子生物学和免疫学，以及内源性FV的最新研究发现。有几个主题聚焦于病毒复制以及病毒蛋白与细胞蛋白之间的相互作用。FV在生物医学研究中的应用通过使用FV载体进行基因治疗以及将FV蛋白用作疫苗抗原呈递支架的相关报告得到了重点介绍。本报告还代表FV研究群体，简短缅怀了逆转录病毒学和泡沫病毒领域的顶尖专家之一阿克塞尔·雷特维尔姆教授，他于2014年7月29日去世。
