Vlad Mihaela, Golu Ioana, Bota Simona, Vlad Adrian, Timar Bogdan, Timar Romulus, Sporea Ioan
Department of Endocrinology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Wien Klin Wochenschr. 2015 May;127(9-10):330-6. doi: 10.1007/s00508-015-0754-2. Epub 2015 Apr 3.
To evaluate and compare the values of the elasticity index as measured by shear wave elastography in healthy subjects and in patients with autoimmune thyroid disease, in order to establish if this investigation can predict the occurrence of autoimmune thyroid disease.
A total of 104 cases were included in the study group: 91 women (87.5%), out of which 52 (50%) with autoimmune thyroid disease diagnosed by specific tests and 52 (50%) healthy volunteers, matched for age and gender. For all the subjects, three measurements were performed on each thyroid lobe and a mean value was calculated. The data were expressed in kPa. The investigation was performed with an Aixplorer system (SuperSonic Imagine, France), using a linear high-resolution 15-4 MHz transducer.
The mean value for the elasticity index was similar in the right and the left thyroid lobes, both in normal subjects and in patients with autoimmune thyroid disease: 19.6 ± 6.6 vs. 19.5 ± 6.8 kPa, p = 0.92, and 26.6 ± 10.0 vs. 25.8 ± 11.7 kPa, p = 0.71, respectively. This parameter was significantly higher in patients with autoimmune thyroid disease than in controls (p < 0.001). For a cut-off value of 22.3 kPa, which resulted in the highest sum of sensitivity and specificity, the elasticity index assessed by shear wave elastography had a sensitivity of 59.6% and a specificity of 76.9% (AUROC = 0.71; p < 0.001) for predicting the presence of autoimmune thyroid disease.
Quantitative elasticity index measured by shear wave elastography was significantly higher in autoimmune thyroid disease than in normal thyroid parenchyma and may predict the presence of autoimmune thyroid disease.
评估并比较健康受试者和自身免疫性甲状腺疾病患者通过剪切波弹性成像测量的弹性指数值，以确定该检查能否预测自身免疫性甲状腺疾病的发生。
研究组共纳入104例病例：91名女性（87.5%），其中52例（50%）经特定检查诊断为自身免疫性甲状腺疾病，52例（50%）为年龄和性别匹配的健康志愿者。对所有受试者的每个甲状腺叶进行三次测量，并计算平均值。数据以kPa表示。使用Aixplorer系统（法国Supersonic Imagine公司），采用线性高分辨率15-4MHz探头进行检查。
正常受试者和自身免疫性甲状腺疾病患者的左右甲状腺叶弹性指数平均值相似：分别为19.6±6.6与19.5±6.8kPa，p=0.92；以及26.6±10.0与25.8±11.7kPa，p=0.71。该参数在自身免疫性甲状腺疾病患者中显著高于对照组（p<0.001）。对于灵敏度和特异度之和最高的22.3kPa临界值，剪切波弹性成像评估的弹性指数预测自身免疫性甲状腺疾病存在的灵敏度为59.6%，特异度为76.9%（曲线下面积=0.71；p<0.001）。
通过剪切波弹性成像测量的定量弹性指数在自身免疫性甲状腺疾病中显著高于正常甲状腺实质，可能预测自身免疫性甲状腺疾病的存在。
