Donado-Godoy Pilar, Byrne Barbara A, León Maribel, Castellanos Ricardo, Vanegas Consuelo, Coral Adriana, Arevalo Alejandra, Clavijo Viviana, Vargas Mercedes, Romero Zuñiga Juan J, Tafur McAllister, Pérez-Gutierrez Enrique, Smith Woutrina A
Corporación Colombiana de Investigación Agropecuaria (CORPOICA), Centro de Biotecnología y Bioindustria (CBB), Kilometro 14, Vía Mosquera, Cundinamarca, Colombia.
School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
J Food Prot. 2015 Apr;78(4):751-9. doi: 10.4315/0362-028X.JFP-14-349.
As a step toward implementing the Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS), this study aimed to establish the baseline antimicrobial resistance patterns of Salmonella serovars, Escherichia coli, and Enterococcus spp. isolates in retail poultry meat from independent stores and from a main chain distributor center. MICs of the isolates were determined for antimicrobials used both in humans and animals, using an automated system. Salmonella serovars were isolated from 26% of the meat samples and E. coli from 83%, whereas Enterococcus faecalis and Enterococcus faecium were detected in 81 and 13% of the meat samples, respectively. A principal finding of concern in this study was that almost 98% of isolates tested were multidrug resistant. Ceftiofur, enrofloxacin, nalidixic acid, and tetracycline were the antimicrobials that showed the highest frequency of resistance among Salmonella and E. coli isolates. For enterococci, 61.5% of E. faecium isolates were found to be resistant to quinupristin-dalfopristin; this is significant because it is used to treat nosocomial infections when vancomycin resistance is present. Vancomycin resistance was detected in 4% of the E. faecalis isolates. The results of our study highlight the need for rapid implementation of an integrated program for surveillance of antimicrobial resistance by the Colombian authorities in order to monitor trends, raise awareness, and help promote practices to safeguard later generation antimicrobial agents.
作为实施哥伦比亚抗菌药物耐药性监测综合计划（COIPARS）的一个步骤，本研究旨在确定独立商店和一家主要连锁经销商中心零售禽肉中沙门氏菌血清型、大肠杆菌和肠球菌属分离株的抗菌药物耐药性基线模式。使用自动化系统测定分离株对人和动物使用的抗菌药物的最低抑菌浓度（MIC）。26%的肉样中分离出沙门氏菌血清型，83%的肉样中分离出大肠杆菌，而粪肠球菌和屎肠球菌分别在81%和13%的肉样中检测到。本研究中一个令人担忧的主要发现是，几乎98%的测试分离株具有多重耐药性。头孢噻呋、恩诺沙星、萘啶酸和四环素是沙门氏菌和大肠杆菌分离株中耐药频率最高的抗菌药物。对于肠球菌，发现61.5%的屎肠球菌分离株对奎奴普丁-达福普汀耐药；这一点很重要，因为当出现万古霉素耐药时，它用于治疗医院感染。在4%的粪肠球菌分离株中检测到万古霉素耐药。我们的研究结果突出表明，哥伦比亚当局需要迅速实施抗菌药物耐药性监测综合计划，以便监测趋势、提高认识并帮助推广保护下一代抗菌药物的做法。
