Li Guo-Liang, Yang Lin, Cui Chang-Cong, Sun Chao-Feng, Yan Gan-Xin
Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, China; Department of Cardiovascular Medicine, Lankenau Medical Center and Lankenau Institute of Medical Research; Department of Cardiovascular Medicine, Jefferson Medical College of Thomas Jefferson University, PA, USA, .
Chin Med J (Engl). 2015 Apr 5;128(7):969-75. doi: 10.4103/0366-6999.154320.
The objective was to provide a brief history of J wave syndromes and to summarize our current understanding of their molecular, ionic, cellular mechanisms, and clinical features. We will also discuss the existing debates and further direction in basic and clinical research for J wave syndromes.
The publications on key words of "J wave syndromes", "early repolarization syndrome (ERS)", "Brugada syndrome (BrS)" and "ST-segment elevation myocardial infarction (STEMI)" were comprehensively reviewed through search of the PubMed literatures without restriction on the publication date.
Original articles, reviews and other literatures concerning J wave syndromes, ERS, BrS and STEMI were selected.
J wave syndromes were firstly defined by Yan et al. in a Chinese journal a decade ago, which represent a spectrum of variable phenotypes characterized by appearance of prominent electrocardiographic J wave including ERS, BrS and ventricular fibrillation (VF) associated with hypothermia and acute STEMI. J wave syndromes can be inherited or acquired and are mechanistically linked to amplification of the transient outward current (I to )-mediated J waves that can lead to phase 2 reentry capable of initiating VF.
J wave syndromes are a group of newly highlighted clinical entities that share similar molecular, ionic and cellular mechanism and marked by amplified J wave on the electrocardiogram and a risk of VF. The clinical challenge ahead is to identify the patients with J wave syndromes who are at risk for sudden cardiac death and determine the alternative therapeutic strategies to reduce mortality.
本文旨在简要介绍J波综合征的历史，并总结目前我们对其分子、离子、细胞机制及临床特征的认识。我们还将讨论J波综合征基础和临床研究中存在的争议及未来的研究方向。
通过检索PubMed文献，全面回顾了关于“J波综合征”“早期复极综合征（ERS）”“Brugada综合征（BrS）”及“ST段抬高型心肌梗死（STEMI）”等关键词的相关出版物，且对发表日期无限制。
选取了有关J波综合征、ERS、BrS及STEMI的原创文章、综述及其他文献。
J波综合征由Yan等人于十年前在中国期刊上首次定义，它代表了一系列不同的表型，其特征为心电图上出现明显的J波，包括ERS、BrS以及与低温和急性STEMI相关的室颤（VF）。J波综合征可遗传或后天获得，其机制与瞬时外向电流（Ito）介导的J波放大有关，这可能导致能够引发VF的2期折返。
J波综合征是一组新被关注的临床实体，它们具有相似的分子、离子和细胞机制，以心电图上J波放大及VF风险为特征。未来临床面临的挑战是识别有心脏性猝死风险的J波综合征患者，并确定降低死亡率的替代治疗策略。
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