Yu Li-Yun, Pei Yu
Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
Chin Med J (Engl). 2015 Apr 5;128(7):976-81. doi: 10.4103/0366-6999.154323.
To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action.
The study is based on the data from PubMed.
Articles were selected with the search terms "insulin", "blood glucose", "neuroprotection", "brain", "glycogen", "cerebral ischemia", "neuronal necrosis", "glutamate", "γ-aminobutyric acid".
Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia.
Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6-9 mmol/L.
分析胰岛素的神经保护机制以及哪个血糖范围有利于胰岛素发挥神经保护作用。
本研究基于来自PubMed的数据。
通过检索词“胰岛素”“血糖”“神经保护”“脑”“糖原”“脑缺血”“神经元坏死”“谷氨酸”“γ-氨基丁酸”选择文章。
胰岛素具有神经保护作用。其机制包括调节神经递质、促进糖原合成以及抑制神经元坏死和凋亡。胰岛素可通过避免低血糖和高血糖发挥其神经保护作用。
对于血糖在6 - 9 mmol/L的缺血性脑损伤患者,间歇性和长期输注胰岛素可能有益。