Buch K, Fujita A, Li B, Kawashima Y, Qureshi M M, Sakai O
From the Departments of Radiology (K.B., A.F., B.L., Y.K., O.S.).
Radiation Oncology (M.M.Q., O.S.).
AJNR Am J Neuroradiol. 2015 Jul;36(7):1343-8. doi: 10.3174/ajnr.A4285. Epub 2015 Apr 2.
Human papillomavirus-associated oropharyngeal squamous cell carcinoma is increasing in prevalence and typically occurs in younger patients than human papillomavirus-negative squamous cell carcinoma. While imaging features of human papillomavirus-positive versus human papillomavirus-negative squamous cell carcinoma nodal metastases have been described, characteristics distinguishing human papillomavirus-positive from human papillomavirus-negative primary squamous cell carcinomas have not been well established. The purpose of this project was to evaluate the use of texture features to distinguish human papillomavirus-positive and human papillomavirus-negative primary oropharyngeal squamous cell carcinoma.
Following institutional review board approval, 40 patients with primary oropharyngeal squamous cell carcinoma and known human papillomavirus status who underwent contrast-enhanced CT between December 2009 and October 2013 were included in this study. Segmentation of the primary lesion was manually performed with a semiautomated graphical-user interface. Following segmentation, an in-house-developed texture analysis program extracted 42 texture features from each segmented volume. A t test was used to evaluate differences in texture parameters between human papillomavirus-positive and human papillomavirus-negative squamous cell carcinomas.
Of the 40 included patients, 29 had human papillomavirus-positive oropharyngeal squamous cell carcinoma and 11 had human papillomavirus-negative oropharyngeal squamous cell carcinoma. Significant differences were seen in the histogram parameters median (P = .006) and entropy (P = .016) and squamous cell carcinoma entropy (P = .043).
There are statistically significant differences in some texture features between human papillomavirus-positive and human papillomavirus-negative oropharyngeal tumors. Texture analysis may be considered an adjunct to the evaluation of human papillomavirus status and characterization of squamous cell carcinoma.
人乳头瘤病毒相关的口咽鳞状细胞癌患病率正在上升，且与乳头瘤病毒阴性的鳞状细胞癌相比，其发病患者通常更年轻。虽然已经描述了人乳头瘤病毒阳性与阴性鳞状细胞癌淋巴结转移的影像学特征，但区分人乳头瘤病毒阳性与阴性原发性鳞状细胞癌的特征尚未完全明确。本项目的目的是评估利用纹理特征区分人乳头瘤病毒阳性和阴性原发性口咽鳞状细胞癌的可行性。
经机构审查委员会批准，本研究纳入了2009年12月至2013年10月期间接受增强CT检查、患有原发性口咽鳞状细胞癌且已知人乳头瘤病毒状态的40例患者。使用半自动图形用户界面手动分割原发性病变。分割后，一个内部开发的纹理分析程序从每个分割体积中提取42个纹理特征。采用t检验评估人乳头瘤病毒阳性和阴性鳞状细胞癌之间纹理参数的差异。
在纳入的40例患者中，29例为人乳头瘤病毒阳性的口咽鳞状细胞癌，11例为人乳头瘤病毒阴性的口咽鳞状细胞癌。在直方图参数中位数（P = 0.006）、熵（P = 0.016）和鳞状细胞癌熵（P = 0.043）方面存在显著差异。
人乳头瘤病毒阳性和阴性口咽肿瘤在某些纹理特征上存在统计学显著差异。纹理分析可被视为评估人乳头瘤病毒状态和鳞状细胞癌特征的辅助手段。
