Parodi Maurizio Battaglia, Iacono Pierluigi, Triolo Giacinto, La Spina Carlo, Zucchiatti Ilaria, Cicinelli Maria Vittoria, Borrelli Enrico, Manitto Maria Pia, Martina Elisabetta, Bandello Francesco
Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy.
Department of Ophthalmology, Fondazione G. B. Bietti per l'Oftalmologia, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy.
Br J Ophthalmol. 2015 Oct;99(10):1354-9. doi: 10.1136/bjophthalmol-2014-306237. Epub 2015 Apr 2.
To correlate patterns in short-wavelength (SW) and near-infrared (NIR) fundus autofluorescence (FAF) with morpho-functional outcomes in eyes affected by Stargardt disease.
Fifty-four eyes of 27 patients were prospectively enrolled. All patients underwent a complete ophthalmologic examination including SW-FAF, NIR-FAF, microperimetry and spectral-domain optical coherence tomography (SD-OCT). The main outcome measures were identification of a correlation between NIR-FAF and SW-FAF patterns within the foveal region and best corrected visual acuity (BCVA) values. Secondary outcome measures were correlation of FAF patterns with SD-OCT findings and retinal sensitivity on microperimetry.
Eyes showing a pattern of foveal hyper-FAF on NIR-FAF had a higher BCVA than eyes with a reduced FAF signal (0.44±0.23 LogMAR vs 1.08±0.19, p<0.001). Similarly, mean sensitivity within 2° of the foveal region was significantly better (6.45±2.39 dB) in eyes with hyper-FAF than in eyes with hypo-FAF (0.23±0.45 dB, p<0.001). Moreover, eyes with hyper-FAF on SW-FAF did not present a significant difference in BCVA (0.73±0.31 vs 0.83±0.43, p=0.335) and mean retinal sensitivity (4.34±3.91 dB vs 2.33±2.96, p=0.07) compared with the subgroup with foveal hypo-FAF. The integrity of both the photoreceptor inner/outer segment junction and the photoreceptor outer segment/retinal pigmented epithelium junction was significantly correlated with a preserved BCVA and a foveal hyper-FAF pattern on NIR-FAF.
Our data suggest that NIR-FAF patterns correlate with morpho-functional outcomes in eyes affected by Stargardt disease. Longitudinal investigations are warranted to assess more precisely the actual contribution of NIR-FAF in the clinical characterisation of Stargardt disease.
将短波长（SW）和近红外（NIR）眼底自发荧光（FAF）模式与患有斯塔加特病的眼睛的形态功能结果相关联。
前瞻性纳入27例患者的54只眼睛。所有患者均接受了包括SW-FAF、NIR-FAF、微视野检查和光谱域光学相干断层扫描（SD-OCT）在内的完整眼科检查。主要结局指标是确定中央凹区域内NIR-FAF和SW-FAF模式之间的相关性以及最佳矫正视力（BCVA）值。次要结局指标是FAF模式与SD-OCT检查结果以及微视野检查中视网膜敏感度的相关性。
NIR-FAF显示中央凹高自发荧光模式的眼睛的BCVA高于自发荧光信号降低的眼睛（0.44±0.23 LogMAR对1.08±0.19，p<0.001）。同样，高自发荧光眼睛中央凹区域2°范围内的平均敏感度（6.45±2.39 dB）明显优于低自发荧光眼睛（0.23±0.45 dB，p<0.001）。此外，与中央凹低自发荧光亚组相比，SW-FAF高自发荧光的眼睛在BCVA（0.73±0.31对0.83±0.43，p=0.335）和平均视网膜敏感度（4.34±3.91 dB对2.33±2.96，p=0.07）方面没有显著差异。光感受器内/外段交界处和光感受器外段/视网膜色素上皮交界处的完整性与保留的BCVA和NIR-FAF上的中央凹高自发荧光模式显著相关。
我们的数据表明，NIR-FAF模式与患有斯塔加特病的眼睛的形态功能结果相关。有必要进行纵向研究，以更精确地评估NIR-FAF在斯塔加特病临床特征中的实际作用。
