Department of EyeSmart EMR and AEye; Department of Ophthalmology, Indian Health Outcomes, Public Health, and Economics Research Center, L V Prasad Eye Institute, Hyderabad, Telangana, India, Telangana.
Department of Ophthalmology, Indian Health Outcomes, Public Health, and Economics Research Center; Department of Ophthalmology, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2023 Oct;71(10):3407-3411. doi: 10.4103/IJO.IJO_3290_22.
To describe the demographics and clinical profile of Stargardt disease in patients presenting a multitier ophthalmology hospital network in India.
This cross-sectional hospital-based study was performed among 2,834,616 new patients presenting between August 2010 and June 2021 in our network. Patients with a clinical diagnosis of Stargardt disease in at least one eye were included as cases. The data were collected using an electronic medical record system.
Overall, 1,934 (0.069%) patients were diagnosed with Stargardt disease. Most of the patients were male (63.14%). The most common age group at presentation was during the second decade of life, with 626 (31.87%) patients. The overall prevalence was higher in patients from a higher socioeconomic status (0.077%), in those presenting from the urban geography (0.079%), and in students (0.197%). Systemic history of hypertension was seen in 56 (2.85%) patients, while diabetes mellitus was seen in (2.49%) patients. Of the 3,917 eyes, 1,910 (48.76%) eyes had moderate visual impairment (>20/70-20/200) followed by severe visual impairment (>20/200 to 20/400) in 646 (16.49%) eyes. The most commonly associated retinal signs were retinal flecks in 1,260 (32.17%) eyes, followed by RPE changes in 945 (24.13%) eyes. The most documented investigations were autofluorescence (39.85%), followed by optical coherence tomography (23.90). Cataract surgery was the commonest performed surgical intervention in (0.66%) eyes, followed by intravitreal injection in 4 (0.10%) eyes. The family history of parent consanguinity marriage was reported by 212 (10.79%) patients.
Stargardt disease was seen more commonly in males presenting during the second decade of life. It is predominantly a bilateral disease, with the majority of the eyes having moderate visual impairment.
描述在印度一家多级别眼科医院网络就诊的 Stargardt 病患者的人口统计学和临床特征。
本横断面医院病例研究纳入了 2010 年 8 月至 2021 年 6 月期间在我们网络就诊的 2834616 名新患者。将至少一只眼临床诊断为 Stargardt 病的患者作为病例纳入研究。数据通过电子病历系统收集。
总体而言，1934 名（0.069%）患者被诊断为 Stargardt 病。大多数患者为男性（63.14%）。就诊时最常见的年龄组为第二个十年，有 626 名（31.87%）患者。来自较高社会经济地位（0.077%）、来自城市地区（0.079%）和学生（0.197%）的患者总体患病率更高。56 名（2.85%）患者有高血压病史，24 名（2.49%）患者有糖尿病病史。在 3917 只眼中，1910 只（48.76%）眼有中度视力障碍（>20/70-20/200），其次是 646 只（16.49%）眼有严重视力障碍（>20/200 至 20/400）。最常见的视网膜病变体征是视网膜斑点 1260 只（32.17%），其次是 RPE 改变 945 只（24.13%）。最常见的检查是自发荧光（39.85%），其次是光学相干断层扫描（23.90%）。白内障手术是最常见的眼部手术干预措施（0.66%），其次是 4 只眼（0.10%）进行玻璃体腔内注射。212 名（10.79%）患者报告有父母近亲结婚史。
Stargardt 病在第二十年纪就诊的男性中更为常见。它主要是一种双侧疾病，大多数眼睛有中度视力障碍。
