Passos Emanuel, Ascensão António, Martins Maria João, Magalhães José
Department of Biochemistry, Faculty of Medicine and Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
Metabolism. 2015 Jul;64(7):780-92. doi: 10.1016/j.metabol.2015.02.003. Epub 2015 Feb 23.
Sedentary lifestyle coupled with excessive consumption of high caloric food has been related to the epidemic increase of non-alcoholic fatty liver disease, which can progress from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis and, eventually, may culminate in hepatocellular carcinoma. Although the precise mechanisms underlying the progression of NASH are not completely understood, endoplasmic reticulum (ER) dysfunction seems to play a key role in the process. Hepatic ER stress has been associated to hepatic steatosis, insulin resistance, inflammation, oxidative stress and hepatocyte death, contributing to liver dysfunction. Physical exercise seems to be the most effective preventive and therapeutic non-pharmacological strategy to mitigate several features related to NASH, possibly targeting most of the referred mechanisms associated with the pathophysiology of ER-related NASH. Nevertheless, little is known about the impact of physical exercise on NASH-related ER stress. In this review, we will discuss the ER stress associated to NASH conditions and highlight the possible benefits of physical exercise in the attenuation and/or reversion of NASH-related ER stress.
久坐不动的生活方式加上高热量食物的过量摄入与非酒精性脂肪性肝病的流行增加有关，这种疾病可从单纯性脂肪变性发展为非酒精性脂肪性肝炎（NASH）、纤维化、肝硬化，并最终可能发展为肝细胞癌。尽管NASH进展的确切机制尚未完全了解，但内质网（ER）功能障碍似乎在这一过程中起关键作用。肝脏内质网应激与肝脏脂肪变性、胰岛素抵抗、炎症、氧化应激和肝细胞死亡有关，导致肝功能障碍。体育锻炼似乎是减轻与NASH相关的几种特征的最有效的非药物预防和治疗策略，可能针对与内质网相关的NASH病理生理学相关的大多数上述机制。然而，关于体育锻炼对NASH相关内质网应激的影响知之甚少。在这篇综述中，我们将讨论与NASH状况相关的内质网应激，并强调体育锻炼在减轻和/或逆转NASH相关内质网应激方面的可能益处。
