de Sousa Fernandes Matheus Santos, Badicu Georgian, Santos Gabriela Carvalho Jurema, Filgueira Tayrine Ordonio, Henrique Rafael Dos Santos, de Souza Raphael Fabrício, Aidar Felipe J, Souto Fabrício Oliveira, Brum Patrícia Chakur, Lagranha Claudia Jacques
Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife 507400-600, Pernambuco, Brazil.
Department of Physical Education and Special Motricity, Transilvania University of Brasov, 500068 Brasov, Romania.
Eur J Investig Health Psychol Educ. 2023 Jun 19;13(6):1082-1096. doi: 10.3390/ejihpe13060082.
Endoplasmic reticulum stress (ER stress) affects many tissues and contributes to the development and severity of chronic diseases. In contrast, regular physical exercise (PE) has been considered a powerful tool to prevent and control several chronic diseases. The present systematic review aimed to evaluate the impact of different PE protocols on ER stress markers in central and peripheral tissues in rodents. The eligibility criteria were based on PICOS (population: rodents; intervention: physical exercise/physical training; control: animals that did not undergo training; outcomes: endoplasmic reticulum stress; studies: experimental). The PubMed/Medline, Science Direct, Scopus, and Scielo databases were analyzed systematically. Quality assessment was performed using SYRCLE's risk of bias tool for animal studies. The results were qualitatively synthesized. Initially, we obtained a total of 2.490 articles. After excluding duplicates, 30 studies were considered eligible. Sixteen studies were excluded for not meeting the eligibility criteria. Therefore, 14 articles were included. The PE protocol showed decreased levels/expression of markers of ER stress in the central and peripheral tissues of rodents. PE can decrease ER stress by reducing cellular stress in the cardiac, brain, and skeletal muscle tissues in rodents. However, robust PE protocols must be considered, including frequency, duration, and intensity, to optimize the PE benefits of counteracting ER stress and its associated conditions.
内质网应激（ER应激）影响许多组织，并促成慢性疾病的发展和严重程度。相比之下，规律的体育锻炼（PE）被认为是预防和控制多种慢性疾病的有力工具。本系统评价旨在评估不同体育锻炼方案对啮齿动物中枢和外周组织中内质网应激标志物的影响。纳入标准基于PICOS（人群：啮齿动物；干预：体育锻炼/体能训练；对照：未接受训练的动物；结局：内质网应激；研究：实验性研究）。对PubMed/Medline、Science Direct、Scopus和Scielo数据库进行了系统分析。使用SYRCLE的动物研究偏倚风险工具进行质量评估。对结果进行了定性综合分析。最初，我们共获得2490篇文章。排除重复项后，30项研究被认为符合条件。16项研究因不符合纳入标准而被排除。因此，纳入了14篇文章。体育锻炼方案显示啮齿动物中枢和外周组织中内质网应激标志物的水平/表达降低。体育锻炼可通过减轻啮齿动物心脏、大脑和骨骼肌组织中的细胞应激来降低内质网应激。然而，必须考虑包括频率、持续时间和强度在内的有力的体育锻炼方案，以优化体育锻炼在对抗内质网应激及其相关病症方面的益处。
