白细胞介素作为口腔癌死亡率和复发生物标志物的潜在作用。

Possible role for interleukins as biomarkers for mortality and recurrence in oral cancer.

作者信息

Arduino Paolo G, Menegatti Elisa, Cappello Nazario, Martina Eugenio, Gardino Nicolò, Tanteri Carlotta, Cavallo Franco, Scully Crispian, Broccoletti Roberto

机构信息

1 Department of Surgical Sciences, University of Turin, Turin - Italy.

出版信息

Int J Biol Markers. 2015 May 26;30(2):e262-6. doi: 10.5301/jbm.5000142.

DOI:10.5301/jbm.5000142

PMID:25838055

Abstract

BACKGROUND

Salivary and serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) have previously been studied in oral cancer with conflicting results.

METHODS

We designed a controlled study to assess the correlation between pretreatment salivary and serum levels of IL-6 and IL-8, and all-cause survival and cancer recurrence in oral cancer patients.

RESULTS

Fifty-two oral cancer patients and 52 healthy control cases were selected. In univariate analysis, salivary IL-6 and IL-8 seemed to be more expressed in cases (p<0.001 and p = 0.010, respectively). Multivariate analysis showed that higher pretreatment saliva IL-6 levels were significantly associated with better survival (hazard ratio [HR] = 8.62; 95% confidence interval [95% CI], 1.21-62.50; p = 0.031).

CONCLUSIONS

To date, this is the largest prospective controlled study that has analyzed the pretreatment salivary and serum levels of IL-6 and IL-8 in oral cancer patients, suggesting salivary IL-6 as a possible prognostic biomarker. But further validation in a larger sample is still necessary.

摘要

背景

此前对口腔癌患者唾液和血清中白细胞介素-6（IL-6）及白细胞介素-8（IL-8）水平进行了研究，但结果相互矛盾。

方法

我们设计了一项对照研究，以评估口腔癌患者治疗前唾液和血清中IL-6及IL-8水平与全因生存率及癌症复发之间的相关性。

结果

选取了52例口腔癌患者和52例健康对照者。单因素分析显示，病例组中唾液IL-6和IL-8表达似乎更高（分别为p<0.001和p = 0.010）。多因素分析表明，治疗前唾液IL-6水平较高与更好的生存率显著相关（风险比[HR]=8.62；95%置信区间[95%CI]，1.21 - 62.50；p = 0.031）。