Singh V, Singla S K, Jha V, Puri V, Puri S
Department of Biochemistry, Panjab University, Chandigarh, India.
Department of Nephrology, PGIMER, Chandigarh, India.
Indian J Nephrol. 2015 Mar-Apr;25(2):70-6. doi: 10.4103/0971-4065.139492.
The understanding of the genomics of the renal tissue has gathered a considerable interest and is making rapid progress. The molecular mechanisms as well as the precise function of the associated molecular components toward renal pathophysiology have recently been realized. For the cystic kidney disease, the regulation of gene expression affecting epithelial cells proliferation, apoptosis as well as process of differentiation/de-differentiation represent key molecular targets. For the cystic disorders, molecular targets have been identified, which besides lending heterogeneity to cysts may also provide tools to unravel their functional importance to understand the renal tissue homeostasis. This review focuses on providing comprehensive information about the transcriptional regulatory role of hepatocyte nuclear factor-1β, a homeoprotein, as well as its interacting partners in renal tissue development and pathophysiology.
对肾组织基因组学的理解已引起了相当大的关注，并正在迅速取得进展。最近已经认识到相关分子成分对肾脏病理生理学的分子机制及其精确功能。对于多囊肾病，影响上皮细胞增殖、凋亡以及分化/去分化过程的基因表达调控是关键分子靶点。对于囊性疾病，已经确定了分子靶点，这些靶点除了使囊肿具有异质性外，还可能提供工具来揭示它们对理解肾组织稳态的功能重要性。本综述着重提供有关肝细胞核因子-1β（一种同源蛋白）在肾组织发育和病理生理学中的转录调控作用及其相互作用伙伴的全面信息。
