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利妥昔单抗诱发左束支传导阻滞。

Rituximab induced left bundle branch block.

作者信息

Sheikh Mujeeb, Moza Ankush, Grubb Blair P

机构信息

Department of Medicine, Division of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, Ohio, U.S.A.

出版信息

Heart Views. 2015 Jan-Mar;16(1):21-4. doi: 10.4103/1995-705X.152997.

DOI:10.4103/1995-705X.152997
PMID:25838875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4379638/
Abstract

Rituximab (a monoclonal antibody directed against CD 20) therapy can be acutely complicated by infusion reactions and cardiac arrhythmia on rare occasions. We report the first case of a new onset left bundle branch block (LBBB) after rituximab therapy for Wegener's vasculitis.

摘要

利妥昔单抗（一种针对CD20的单克隆抗体）治疗偶尔会急性并发输注反应和心律失常。我们报告了第一例在使用利妥昔单抗治疗韦格纳肉芽肿后新发左束支传导阻滞（LBBB）的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/62636f6c3e6e/HV-16-21-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/fe1ca9bc9940/HV-16-21-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/ff7f7e1bd34b/HV-16-21-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/ba5697aa0149/HV-16-21-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/62636f6c3e6e/HV-16-21-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/fe1ca9bc9940/HV-16-21-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/ff7f7e1bd34b/HV-16-21-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/ba5697aa0149/HV-16-21-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56b2/4379638/62636f6c3e6e/HV-16-21-g004.jpg

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本文引用的文献

1
Rituximab versus cyclophosphamide for ANCA-associated vasculitis.利妥昔单抗与环磷酰胺治疗抗中性粒细胞胞质抗体相关性血管炎。
N Engl J Med. 2010 Jul 15;363(3):221-32. doi: 10.1056/NEJMoa0909905.
2
Rituximab-induced polymorphic ventricular tachycardia.利妥昔单抗诱发的多形性室性心动过速。
Tex Heart Inst J. 2010;37(2):218-20.
3
Cardiac side-effects of cancer chemotherapy.癌症化疗的心脏副作用。
Int J Cardiol. 2010 Sep 24;144(1):3-15. doi: 10.1016/j.ijcard.2010.03.003. Epub 2010 Apr 18.
4
A phase I-II study to determine the maximum tolerated infusion rate of rituximab with special emphasis on monitoring the effect of rituximab on cardiac function.一项I-II期研究，旨在确定利妥昔单抗的最大耐受输注速率，特别强调监测利妥昔单抗对心脏功能的影响。
Clin Cancer Res. 2008 Dec 1;14(23):7935-9. doi: 10.1158/1078-0432.CCR-08-1124.
5
Complete atrioventricular block induced by rituximab in monotherapy in an aged patient with non-Hodgkin's diffuse large B-cell lymphoma.利妥昔单抗单药治疗引起老年非霍奇金弥漫性大B细胞淋巴瘤患者完全性房室传导阻滞。
Clin Transl Oncol. 2008 May;10(5):298-9. doi: 10.1007/s12094-008-0201-1.
6
B-cell inhibitors as therapy for rheumatoid arthritis: an update.B细胞抑制剂治疗类风湿关节炎的最新进展
Curr Rheumatol Rep. 2007 Oct;9(5):401-6. doi: 10.1007/s11926-007-0064-4.
7
Delayed reduction in left ventricular function following treatment of non-Hodgkin's lymphoma with chemotherapy and rituximab, unrelated to acute infusion reaction.非霍奇金淋巴瘤经化疗和利妥昔单抗治疗后左心室功能延迟降低，与急性输注反应无关。
Cardiology. 2006;105(3):184-7. doi: 10.1159/000091416. Epub 2006 Feb 14.
8
Immunotherapy for thrombotic thrombocytopenic purpura.血栓性血小板减少性紫癜的免疫疗法。
Curr Opin Hematol. 2005 Sep;12(5):359-63. doi: 10.1097/01.moh.0000170534.33517.99.
9
Ventricular tachycardia associated with infusion of rituximab in mantle cell lymphoma.套细胞淋巴瘤中与利妥昔单抗输注相关的室性心动过速。
Am J Hematol. 2005 Apr;78(4):317-8. doi: 10.1002/ajh.20303.
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CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.老年弥漫性大B细胞淋巴瘤患者中，CHOP化疗联合利妥昔单抗与单纯CHOP化疗的比较。
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