Larmi E
Department of Dermatology, University of Oulu, Finland.
Int J Dermatol. 1989 Nov;28(9):609-11. doi: 10.1111/j.1365-4362.1989.tb02540.x.
The effect of trioxsalen bath PUVA therapy on nonimmunologic immediate contact reactions (NIICRs) induced by benzoic acid (BA) and methyl nicotinate (MN) was studied in 12 dermatologic patients. One half of the back skin was covered with a cloth before each of ten irradiations on subsequent days. Four concentrations of each test substance were applied to the PUVA-exposed and nonexposed areas before any irradiation and after the 1st, 5th, and 10th PUVA treatment. Erythema and edema reactions were observed visually 40 minutes after BA and MN application, and changes in the skin blood flow were monitored using laser Doppler flowmetry (LDF). PUVA therapy suppressed the NIICRs in all concentrations of BA and MN on the PUVA-exposed area and occasionally on the nonexposed test sites. The suppressive effect was intesified during therapy.
在12名皮肤科患者中研究了三甲沙林浴光化学疗法（PUVA）对苯甲酸（BA）和烟酸甲酯（MN）诱导的非免疫性即刻接触反应（NIICR）的影响。在随后几天的十次照射中的每次照射前，用一块布覆盖背部皮肤的一半。在任何照射前以及第一次、第五次和第十次PUVA治疗后，将每种测试物质的四种浓度应用于PUVA照射区和未照射区。在应用BA和MN后40分钟肉眼观察红斑和水肿反应，并使用激光多普勒血流仪（LDF）监测皮肤血流变化。PUVA疗法在PUVA照射区以及偶尔在未照射的测试部位抑制了所有浓度的BA和MN引起的NIICR。在治疗期间抑制作用增强。
