Larmi E, Lahti A, Hannuksela M
University of Oulu, Department of Dermatology, Finland.
Contact Dermatitis. 1989 Jan;20(1):38-40. doi: 10.1111/j.1600-0536.1989.tb03093.x.
Benzoic acid (BA) and the sodium salt of pyrrolidone carboxylic acid (NaPCA) were tested in 13 healthy persons to obtain information about, firstly, the irritant properties of NaPCA and, secondly, the reactivity of various skin sites. BA at 16, 8, and 4 mM pet., and NaPCA at 50, 25, 12.5, and 6.25% in water, were applied to the forehead, cheek, neck and upper back. Erythema reactions were observed visually, and the changes in the skin blood flow were monitored using a laser-Doppler flowmeter. BA at 16 mM increased blood flow on the cheek of 12 test subjects, and on the neck, forehead and upper back of 6 subjects, but 8 and 4 mM BA elicited reactions only on the cheek. NaPCA caused reactions on the upper back of 3 test subjects only, but not on other test sites.
对13名健康受试者进行了苯甲酸（BA）和吡咯烷酮羧酸钠（NaPCA）测试，目的一是获取有关NaPCA刺激性的信息，二是了解不同皮肤部位的反应性。将浓度为16、8和4 mM的石油醚中的BA以及浓度为50%、25%、12.5%和6.25%的水中的NaPCA分别涂抹于额头、脸颊、颈部和上背部。通过肉眼观察红斑反应，并使用激光多普勒血流仪监测皮肤血流变化。16 mM的BA使12名受试者脸颊的血流增加，6名受试者颈部、额头和上背部的血流增加，但8 mM和4 mM的BA仅在脸颊引发反应。NaPCA仅在3名受试者的上背部引起反应，而在其他测试部位未引起反应。
