Larmi E, Lahti A, Hannuksela M
University of Oulu, Department of Dermatology, Finland.
Arch Dermatol Res. 1988;280(7):420-3. doi: 10.1007/BF00429981.
The effect of ultraviolet B (UVB) and ultraviolet A (UVA) irradiation on nonimmunologic immediate contact reactions (NIICRs) induced by benzoid acid (BA) was studied in 14 and 13 test subjects, respectively. 10 x 20 cm areas of the back skin were irradiated with 0.08, 0.16, and 0.24 J/cm2 UVB, and with 20 and 60 J/cm2 UVA. Five concentrations of BA were applied to the UV-exposed and nonexposed areas on the 1st, 3rd, 7th, and 21st day after UVB irradiation and on the 1st, 3rd, 7th, and 14th day after UVA irradiation. Forty minutes after BA application, erythema and edema reactions were observed visually, and changes in the skin blood flow were monitored using laser-Doppler flowmetry. The highest dose of UVB significantly inhibited NIICRs for 3 weeks. The lower doses of UVB had a weaker effect. Both doses of UVA diminished blood flow in NIICRs to lower concentrations of BA for 14 days.
分别在14名和13名受试者中研究了紫外线B（UVB）和紫外线A（UVA）照射对苯甲酸（BA）诱导的非免疫性即刻接触反应（NIICRs）的影响。用0.08、0.16和0.24 J/cm²的UVB以及20和60 J/cm²的UVA照射背部10×20 cm区域的皮肤。在UVB照射后的第1、3、7和21天以及UVA照射后的第1、3、7和14天，将五种浓度的BA涂抹于紫外线照射和未照射区域。涂抹BA 40分钟后，肉眼观察红斑和水肿反应，并用激光多普勒血流仪监测皮肤血流变化。最高剂量的UVB可显著抑制NIICRs达3周。较低剂量的UVB作用较弱。两种剂量的UVA在14天内均使NIICRs中对较低浓度BA的血流减少。
