富含鸟嘌呤的DNA寡核苷酸中的离域空穴域

Delocalized hole domains in Guanine-rich DNA oligonucleotides.

作者信息

Capobianco Amedeo, Caruso Tonino, D'Ursi Anna Maria, Fusco Sandra, Masi Annalisa, Scrima Mario, Chatgilialoglu Chryssostomos, Peluso Andrea

机构信息

§Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, I-40129 Bologna, Italy.

∥National Center for Scientific Research "Demokritos", Institute of Nanoscience and Nanotechnology, 15341 Agia Paraskevi, Athens, Greece.

出版信息

J Phys Chem B. 2015 Apr 30;119(17):5462-6. doi: 10.1021/acs.jpcb.5b02940. Epub 2015 Apr 15.

DOI:10.1021/acs.jpcb.5b02940

PMID:25839102

Abstract

Differential pulse voltammetries of guanine-rich single- and double-stranded oligonucleotides containing up to six consecutive guanines are reported. The observed progressive lowering of the first voltammetric peak potential as the number of adjacent guanines increases unambiguously points toward the establishment of delocalized hole domains; the hole stabilization energy is ca. 0.1 eV per GG step, significantly lower than that observed for AA steps.

摘要

报道了含有多达六个连续鸟嘌呤的富含鸟嘌呤的单链和双链寡核苷酸的差分脉冲伏安法。随着相邻鸟嘌呤数量的增加，观察到的第一个伏安峰电位逐渐降低，这明确指向了离域空穴域的形成；每个GG步的空穴稳定能约为0.1 eV，明显低于AA步所观察到的数值。