2例婴儿期恶性迁移性部分性癫痫患者发作间期脑电图背景的特征
Characteristic Features of the Interictal EEG Background in 2 Patients With Malignant Migrating Partial Epilepsy in Infancy.
作者信息
Selioutski Olga, Seltzer Laurie E, Burchfiel James, Paciorkowski Alex R, Erba Giuseppe
机构信息
*Department of Neurology, University of Rochester Medical Center, Rochester, New York, U.S.A.; †Strong Epilepsy Center, University of Rochester Medical Center, Rochester, New York, U.S.A.; and ‡Departments of Pediatrics and Biomedical Genetics, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York, U.S.A.
出版信息
J Clin Neurophysiol. 2015 Aug;32(4):e23-9. doi: 10.1097/WNP.0000000000000178.
PURPOSE
To describe chronological electrographic features of the interictal EEG background observed in two patients with malignant migrating partial epilepsy in infancy from neonatal to early infantile period.
METHODS
EEGs of two patients who fulfilled diagnostic criteria for malignant migrating partial epilepsy in infancy were acquired over the period of 6 months to monitor treatment efficacy and characterize seizures and other paroxysmal events.
RESULTS
Both patients followed a similar sequential pattern. A distinctive evolution from a dysmature term neonatal EEG pattern to an asynchronous suppression burst pattern was observed before the interictal background becoming continuous.
CONCLUSIONS
Physicians providing care to infants with intractable epilepsy and burst suppression EEG pattern should be alert to the possibility of malignant migrating partial epilepsy in infancy. An earlier diagnosis of malignant migrating partial epilepsy in infancy would help to guide diagnostic workup including genetic testing.
目的
描述两名婴儿恶性迁移性部分性癫痫患者从新生儿期到婴儿早期发作间期脑电图背景的时间顺序性电生理特征。
方法
对两名符合婴儿恶性迁移性部分性癫痫诊断标准的患者进行了为期6个月的脑电图检查，以监测治疗效果并对癫痫发作及其他阵发性事件进行特征描述。
结果
两名患者均遵循相似的顺序模式。在发作间期背景变为连续性之前，观察到从发育不成熟的足月儿新生儿脑电图模式向异步抑制爆发模式的独特演变。
结论
为患有顽固性癫痫和爆发抑制脑电图模式的婴儿提供护理的医生应警惕婴儿恶性迁移性部分性癫痫的可能性。早期诊断婴儿恶性迁移性部分性癫痫将有助于指导包括基因检测在内的诊断检查。
Zotero 插件