Characteristic Features of the Interictal EEG Background in 2 Patients With Malignant Migrating Partial Epilepsy in Infancy.
作者信息
Selioutski Olga, Seltzer Laurie E, Burchfiel James, Paciorkowski Alex R, Erba Giuseppe
机构信息
*Department of Neurology, University of Rochester Medical Center, Rochester, New York, U.S.A.; †Strong Epilepsy Center, University of Rochester Medical Center, Rochester, New York, U.S.A.; and ‡Departments of Pediatrics and Biomedical Genetics, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York, U.S.A.
出版信息
J Clin Neurophysiol. 2015 Aug;32(4):e23-9. doi: 10.1097/WNP.0000000000000178.
PURPOSE
To describe chronological electrographic features of the interictal EEG background observed in two patients with malignant migrating partial epilepsy in infancy from neonatal to early infantile period.
METHODS
EEGs of two patients who fulfilled diagnostic criteria for malignant migrating partial epilepsy in infancy were acquired over the period of 6 months to monitor treatment efficacy and characterize seizures and other paroxysmal events.
RESULTS
Both patients followed a similar sequential pattern. A distinctive evolution from a dysmature term neonatal EEG pattern to an asynchronous suppression burst pattern was observed before the interictal background becoming continuous.
CONCLUSIONS
Physicians providing care to infants with intractable epilepsy and burst suppression EEG pattern should be alert to the possibility of malignant migrating partial epilepsy in infancy. An earlier diagnosis of malignant migrating partial epilepsy in infancy would help to guide diagnostic workup including genetic testing.
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