Grouleff Julie, Irudayam Sheeba Jem, Skeby Katrine K, Schiøtt Birgit
Department of Chemistry and Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Department of Chemistry and Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Biochim Biophys Acta. 2015 Sep;1848(9):1783-95. doi: 10.1016/j.bbamem.2015.03.029. Epub 2015 Apr 1.
The plasma membrane, which encapsulates human cells, is composed of a complex mixture of lipids and embedded proteins. Emerging knowledge points towards the lipids as having a regulating role in protein function. Furthermore, insight from protein crystallography has revealed several different types of lipids intimately bound to membrane proteins and peptides, hereby possibly pointing to a site of action for the observed regulation. Cholesterol is among the lipid membrane constituents most often observed to be co-crystallized with membrane proteins, and the cholesterol levels in cell membranes have been found to play an essential role in health and disease. Remarkably little is known about the mechanism of lipid regulation of membrane protein function in health as well as in disease. Herein, we review molecular dynamics simulation studies aimed at investigating the effect of cholesterol on membrane protein and peptide properties. This article is part of a Special Issue entitled: Lipid-protein interactions.
包裹人体细胞的质膜由脂质和嵌入蛋白的复杂混合物组成。新出现的知识表明脂质在蛋白质功能中具有调节作用。此外，蛋白质晶体学的研究结果揭示了几种与膜蛋白和肽紧密结合的不同类型脂质，这可能指出了观察到的调节作用的作用位点。胆固醇是最常被观察到与膜蛋白共结晶的脂质膜成分之一，并且发现细胞膜中的胆固醇水平在健康和疾病中起着至关重要的作用。关于健康和疾病状态下脂质对膜蛋白功能的调节机制，人们所知甚少。在此，我们综述了旨在研究胆固醇对膜蛋白和肽特性影响的分子动力学模拟研究。本文是名为“脂质-蛋白质相互作用”的特刊的一部分。
