Velasco M, Velasco F, Cepeda C, Almanza X, Velasco A L
Scientific Research Department, National Medical Center, IMSS, Mexico City, Mexico.
Int J Neurosci. 1989 Oct;48(3-4):333-46. doi: 10.3109/00207458909002180.
Amplitude and latency changes of early and late components of surface and depth auditory evoked potentials were determined during wakefulness-sleep steady state shifts in epileptic patients, with implanted electrodes used as an electrophysiological procedure for surgical treatment of temporal lobe seizures. Early surface (I and V) and depth (N8 and N15) components of the auditory brainstem potentials and late surface (P2 and N2) and depth (B and C) components of the auditory evoked potentials were produced by either 8/s or single clicks, delivered monoaurally and simultaneously recorded from the vertex and contralateral thalamic (lateral geniculate thalamic nucleus) and frontotemporal (amygdala, hippocampus and orbitofrontal cortex) regions, while patients spontaneously shifted from initial wakefulness (W1) to slow wave sleep (SWS I, II and IV), to paradoxical sleep (PS) and to final wakefulness (W2). Amplitude of late surface (P2 and N2) and depth (B and C) components significantly decreased when patients shifted from SWS IV to PS and increased from PS to W2. Latency of components P2 and B increased while that of components N2 and C decreased from SWS IV to PS. No latency changes in late components were found from PS to W2. In addition, amplitude and latency of P2 and B components significantly decreased while those of N2 and C increased from W1 to SWS IV. Polarity of all late components remained unchangeable during all wakefulness-sleep state shifts, with the exception of that of component C which reversed from W1 to SWS IV. In contrast, early surface (I and V) and depth (N8 and 15) components showed no systematic changes in amplitude and latency during all consecutive wakefulness-sleep shifts, with the exception of a significant increase amplitude but no latency of component V from PS to W1.
在癫痫患者从清醒-睡眠稳态转换过程中，使用植入电极作为颞叶癫痫手术治疗的电生理程序，测定了表面和深度听觉诱发电位早期和晚期成分的振幅和潜伏期变化。听觉脑干电位的早期表面成分（I和V）和深度成分（N8和N15）以及听觉诱发电位的晚期表面成分（P2和N2）和深度成分（B和C），通过每秒8次的刺激或单次点击产生，单耳给药，并同时从头顶、对侧丘脑（外侧膝状体丘脑核）以及额颞叶（杏仁核、海马体和眶额皮质）区域进行记录，同时患者从初始清醒状态（W1）自发转换为慢波睡眠（SWS I、II和IV）、异相睡眠（PS）以及最终清醒状态（W2）。当患者从SWS IV转换为PS时，晚期表面成分（P2和N2）和深度成分（B和C）的振幅显著降低，而从PS转换为W2时则增加。从SWS IV到PS，成分P2和B的潜伏期增加，而成分N2和C的潜伏期减少。从PS到W2，晚期成分未发现潜伏期变化。此外，从W1到SWS IV，P2和B成分的振幅和潜伏期显著降低，而N2和C成分的振幅和潜伏期增加。除了成分C从W1到SWS IV极性反转外，所有晚期成分的极性在所有清醒-睡眠状态转换过程中均保持不变。相比之下，早期表面成分（I和V）和深度成分（N8和15）在所有连续的清醒-睡眠转换过程中，振幅和潜伏期均未显示出系统性变化，但从PS到W1，成分V的振幅显著增加但潜伏期未变。
