Paik Jean Kyung, Kim Minkyung, Kim Minjoo, Yen Yuna, Ahn Hyeon Yeong, Lee Sang-Hyun, Lee Jong Ho
Age (Dordr). 2015;37(2):32. doi: 10.1007/s11357-015-9770-4.
Controversy remains regarding whether there is an association between circulating lipoprotein-associated phospholipase A2 (Lp-PLA2), cytokines, and oxidative stress in healthy postmenopausal women. We investigated the influence of age on Lp-PLA2 activity in postmenopausal women not using hormone therapy and the relationship of Lp-PLA2 enzyme activity to serum cytokine levels and oxidative stress indices. Normal weight (n = 1284) and overweight/obese (n = 707) postmenopausal women not using hormone therapy were categorized into five age groups: 50-54, 55-59, 60-64, 65-69, and 70-89 years. Overweight-obese women showed higher plasma Lp-PLA2 activity, urinary 8-epi-prostaglandin F2α (8-epi-PGF2α), serum interleukin (IL)-6, and smaller LDL particles than normal-weight women after adjusting for age, years postmenopause, smoking, drinking, blood pressure, glucose, insulin, lipid profiles, BMI, and waist circumference. Overweight/obese women 70-89 years old showed higher Lp-PLA2 activity than those aged 50-54 years, whereas no significant difference in Lp-PLA2 activity existed across normal-weight female age groups. Overweight/obese women aged ≥ 65 years showed higher Lp-PLA2, oxidized LDL (ox-LDL), IL-6, and 8-epi-PGF2α than age-matched normal-weight controls. Overweight/obese women aged ≥ 70 years had higher ox-LDL levels than those aged 50-59, and overweight/obese women aged 65-89 showed higher IL-6 and 8-epi-PGF2α. There were strong positive correlations between Lp-PLA2 and ox-LDL (r = 0.385, P < 0.001), Lp-PLA2 and IL-6 (r = 0.293, P < 0.001), and ox-LDL and IL-6 (r = 0.303, P < 0.001) in overweight/obese women; however, these relationships were weak in normal-weight women. These results suggest that aging and obesity-related oxidative and inflammatory mediators are associated with Lp-PLA2 activity in overweight/obese postmenopausal women not using hormone therapy.
健康绝经后女性中，循环脂蛋白相关磷脂酶A2（Lp-PLA2）、细胞因子与氧化应激之间是否存在关联仍存在争议。我们研究了年龄对未使用激素治疗的绝经后女性Lp-PLA2活性的影响，以及Lp-PLA2酶活性与血清细胞因子水平和氧化应激指标的关系。将未使用激素治疗的正常体重（n = 1284）和超重/肥胖（n = 707）绝经后女性分为五个年龄组：50 - 54岁、55 - 59岁、60 - 64岁、65 - 69岁和70 - 89岁。在调整年龄、绝经年限、吸烟、饮酒、血压、血糖、胰岛素、血脂谱、BMI和腰围后，超重肥胖女性的血浆Lp-PLA2活性、尿8-表前列腺素F2α（8-epi-PGF2α）、血清白细胞介素（IL）-6水平更高，低密度脂蛋白颗粒更小。70 - 89岁的超重/肥胖女性的Lp-PLA2活性高于50 - 54岁的女性，而正常体重女性各年龄组之间Lp-PLA2活性无显著差异。≥65岁的超重/肥胖女性的Lp-PLA2、氧化型低密度脂蛋白（ox-LDL）、IL-6和8-epi-PGF2α水平高于年龄匹配的正常体重对照。≥70岁的超重/肥胖女性的ox-LDL水平高于50 - 59岁的女性，65 - 89岁的超重/肥胖女性的IL-6和8-epi-PGF2α水平更高。超重/肥胖女性中，Lp-PLA2与ox-LDL（r = 0.385，P < 0.001）、Lp-PLA2与IL-6（r = 0.293，P < 0.001）以及ox-LDL与IL-6（r = 0.303，P < 0.001）之间存在强正相关；然而，在正常体重女性中，这些关系较弱。这些结果表明，在未使用激素治疗的超重/肥胖绝经后女性中，与衰老和肥胖相关的氧化和炎症介质与Lp-PLA2活性有关。
