Sowiński P, Gariboldi P, Pawlak J K, Borowski E
Department of Pharmaceutical Technology and Biochemistry Technical University of Gdańsk, Poland.
J Antibiot (Tokyo). 1989 Nov;42(11):1639-42. doi: 10.7164/antibiotics.42.1639.
On the basis of coupling constants and rotating frame nuclear Overhauser effect spectroscopy of vacidin A methoxycarbonylmethylamide, the stereochemistry of the antibiotic was established. The configuration of the aglycone was determined as (3R,7R,9R,11S,13S,15R,17S,18R,19S,21R, 36S,37R,38S). The aminosugar constituent of the antibiotic was identified as beta-(D)-mycosamine. The chiral center at C-41 remains to be assigned.
