Pilipenko V I, Tepliuk D A, Shakhovskaia A K, Isakov V A
Eksp Klin Gastroenterol. 2014(7):55-8.
High-resolution manometry (HRM) is increasingly used in the evaluation of anorectal disorders. However, the normal values of HRM have not been widely evaluated. Anorectal pressure patterns are known to be possibly influenced by maternity status in women, but the normal values of HRM in parous and non-parous asymptomatic women have not been studied. The aim of the present study was to evaluate, for the first time, the normal values HRM in asymptomatic parous and non-parous women.
Sixteen asymptomatic healthy females (age: 18-63 years) were enrolled into this study, and among them, 11 were parous women. HRM was performed using solid-state manometric assembly with 9 circumferential pressure sensors (MMS, Netherlands). Measurements of external and internal anal sphincter pressure at rest, during voluntary contraction and during rectal balloon distension were compared..
In asymptomatic parous women mean external anal sphincter resting pressure (69.9 ± 13.2) was significantly lower then anal pressure (101.2 ± 22.9) in healthy non-parous women. No differences were found between groups in internal sphincter pressure, voluntary contraction or during balloon distension.
The found difference in resting external sphincter pressure between parous and non-parous women have to be taken in account when HRM is used for evaluation of functional defecatory disorders. Further studies for establishing of normal values of anorectal HRM in larger group of healthy controls are badly needed.
高分辨率测压法（HRM）越来越多地用于评估肛肠疾病。然而，HRM的正常值尚未得到广泛评估。已知肛肠压力模式可能受女性生育状况的影响，但尚未对有生育史和无生育史的无症状女性的HRM正常值进行研究。本研究的目的是首次评估有生育史和无生育史的无症状女性的HRM正常值。
16名无症状健康女性（年龄：18 - 63岁）纳入本研究，其中11名是有生育史的女性。使用带有9个圆周压力传感器的固态测压组件（荷兰MMS公司）进行HRM。比较静息状态、自主收缩时和直肠球囊扩张时肛门外括约肌和内括约肌压力的测量值。
无症状有生育史女性的肛门外括约肌平均静息压力（69.9±13.2）显著低于健康无生育史女性的肛门压力（101.2±22.9）。两组在内括约肌压力、自主收缩或球囊扩张期间未发现差异。
当使用HRM评估功能性排便障碍时，必须考虑有生育史和无生育史女性静息时肛门外括约肌压力的差异。急需进一步开展研究以确定更大规模健康对照人群中肛肠HRM的正常值。
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