Dessì Angelica, Pravettoni Chiara, Cesare Marincola Flaminia, Schirru Andrea, Fanos Vassilios
Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section - Azienda Ospedaliero Universitaria, Monserrato, Cagliari, Italy.
Expert Rev Proteomics. 2015 Jun;12(3):309-16. doi: 10.1586/14789450.2015.1034694. Epub 2015 Apr 5.
Adipose tissue is no longer considered as inert; the literature describes the role it plays in the production of many substances, such as adiponectin, visfatin, ghrelin, S100B, apelin, TNF, IL-6 and leptin. These molecules have specific roles in humans and their potential as biomarkers useful for identifying alterations related to intrauterine growth retardation and large for gestational age neonates is emerging. Infants born in such conditions have undergone metabolic changes, such as fetal hypo- or hyperinsulinemia, which may lead to development of dysmetabolic syndrome and other chronic diseases in adulthood. In this review, these biomarkers are analyzed specifically and it is discussed how metabolomics may be an advantageous tool for detection, discrimination and prediction of metabolic alterations and diseases. Thus, a holistic approach, such as metabolomics, could help the prevention and early diagnosis of metabolic syndrome.
脂肪组织不再被视为惰性组织；文献描述了它在许多物质产生过程中所起的作用，如脂联素、内脂素、胃饥饿素、S100B、Apelin、肿瘤坏死因子、白细胞介素 - 6和瘦素。这些分子在人体中具有特定作用，并且它们作为生物标志物用于识别与宫内生长迟缓及大于胎龄儿相关改变的潜力正在显现。在这种情况下出生的婴儿经历了代谢变化，如胎儿低胰岛素血症或高胰岛素血症，这可能导致成年后患代谢综合征和其他慢性疾病。在本综述中，对这些生物标志物进行了具体分析，并讨论了代谢组学如何可能成为检测、区分和预测代谢改变及疾病的有利工具。因此，像代谢组学这样的整体方法有助于代谢综合征的预防和早期诊断。
