Marseglia Lucia, D'Angelo Gabriella, Manti Marta, Aversa Salvatore, Fiamingo Chiara, Arrigo Teresa, Barberi Ignazio, Mamì Carmelo, Gitto Eloisa
Neonatal Intensive Care Unit, Department of Paediatrics, University of Messina, Italy
Neonatal Intensive Care Unit, Department of Paediatrics, University of Messina, Italy.
Int J Immunopathol Pharmacol. 2016 Mar;29(1):23-9. doi: 10.1177/0394632015607952. Epub 2015 Nov 2.
Oxidative stress is involved in several neonatal conditions characterized by an upregulation in the production of oxidative or nitrative free radicals and a concomitant decrease in the availability of antioxidant species. Oxygen, which is obviously vital to survival, can be highly damaging to neonatal tissue which is known to be poorly equipped to neutralize toxic derivatives. Thus, exposure of the newborn infant to high oxygen concentrations during resuscitation at birth increases oxidative damage. Visfatin is an adipocytokine involved in oxidative stress and an important mediator of inflammation that induces dose-dependent production of both pro-inflammatory and anti-inflammatory cytokines. To our knowledge, the diagnostic value of visfatin as a marker of oxidative stress in preterm newborns has not been investigated.
The aim of this study was to evaluate visfatin levels in preterm neonates resuscitated with different concentrations of oxygen in the delivery room.
Fifty-two preterm newborns with gestational age less than 32 weeks, resuscitated randomly with different oxygen concentrations (40%, 60%, or 100%) were enrolled at the University Hospital of Messina, over a 12-month period to evaluate serum visfatin levels at T0 (within 1 h after birth), T24 h, T72 h, and T168 h of life.
At T72 h and T168 h, higher serum visfatin values in the high-oxygen group compared to the low- and mild-oxygen subjects (P=0.002 and P<0.001, respectively) were noted.
The results of this study suggest that visfatin could be a new marker of oxidative stress in preterm newborns.
氧化应激参与多种新生儿疾病，其特征为氧化或硝化自由基生成上调，同时抗氧化物质的可用性降低。氧气对生存至关重要，但对新生儿组织具有高度损害性，因为已知新生儿组织中和有毒衍生物的能力较差。因此，新生儿在出生复苏期间暴露于高氧浓度会增加氧化损伤。内脂素是一种参与氧化应激的脂肪细胞因子，是炎症的重要介质，可诱导促炎和抗炎细胞因子的剂量依赖性产生。据我们所知，内脂素作为早产新生儿氧化应激标志物的诊断价值尚未得到研究。
本研究旨在评估在产房接受不同氧浓度复苏的早产新生儿的内脂素水平。
在墨西拿大学医院，选取52例胎龄小于32周的早产新生儿，在12个月期间内随机接受不同氧浓度（40%、60%或100%）复苏，以评估其出生后1小时内（T0）、出生后24小时（T24 h）、出生后72小时（T72 h）和出生后168小时（T168 h）的血清内脂素水平。
在T72 h和T168 h时，高氧组的血清内脂素值高于低氧组和中氧组（分别为P = 0.002和P < 0.001）。
本研究结果表明，内脂素可能是早产新生儿氧化应激的一个新标志物。
