Alexander G R, Himes J H, Kaufman R B, Mor J, Kogan M
School of Public Health, University of Alabama at Birmingham, USA.
Obstet Gynecol. 1996 Feb;87(2):163-8. doi: 10.1016/0029-7844(95)00386-X.
To develop a current national fetal growth curve that can be used as a common reference point by researchers to facilitate investigations of the predictors and consequences of small and large for gestational age delivery.
Single live births to United States resident mothers in 1991 (n = 3,134,879) were used for the development of this curve, which was compared with four previously published fetal growth curves. Techniques were developed to address cases with implausible birth weight-gestational age combinations and to smooth fetal growth curves across gestational age categories.
In general, the previously published fetal growth curves underestimated the 1991 United States reference curve. This underestimation is most apparent during the latter weeks of gestation, approximately 33-38 weeks.
Our findings indicate that the prevalence of fetal growth restriction (FGR) will vary markedly, depending on the fetal growth curve used. Furthermore, many previously published fetal growth curves no longer provide an up-to-date reference for describing the distribution of birth weight by gestational age and for determining FGR that is consistent with the most recent live birth data for the entire United States.
制定一条当前的全国胎儿生长曲线，可供研究人员用作通用参考点，以促进对小于胎龄儿和大于胎龄儿分娩的预测因素及后果的调查。
利用1991年美国常住母亲的单胎活产数据（n = 3,134,879）来制定此曲线，并将其与之前发表的四条胎儿生长曲线进行比较。开发了一些技术来处理出生体重与孕周组合不合理的情况，并使胎儿生长曲线在不同孕周类别间平滑过渡。
总体而言，之前发表的胎儿生长曲线低估了1991年美国的参考曲线。这种低估在妊娠后期最为明显，大约在33 - 38周。
我们的研究结果表明，胎儿生长受限（FGR）的患病率会因所使用的胎儿生长曲线不同而有显著差异。此外，许多之前发表的胎儿生长曲线已不再能为按孕周描述出生体重分布以及确定与美国最新全样本活产数据一致的FGR提供最新参考。
