University of Miami Miller School of Medicine, Department of Dermatology and Cutaneous Surgery, Miami, USA.
J Eur Acad Dermatol Venereol. 2015 Nov;29(11):2100-3. doi: 10.1111/jdv.13117. Epub 2015 Apr 6.
Argyria is a benign skin disease characterized by blue to slate-grey discoloration that is caused by deposition of silver granules in the skin and/or mucus membranes as a result of long-term ingestion of ionized silver solutions or exposure to airborne silver particles. The skin discoloration can be generalized or localized and is exacerbated by sunlight. The skin discoloration is usually permanent, and until recently, there has been no effective treatment for argyria. Over the past 6 years, a number of case reports and one case series have described cases of argyria that were successfully treated with a 1064 nm Q-switched (QS) neodymium-doped yttrium aluminium garnet (Nd:YAG) laser; however, a review of these studies has never been reported in the dermatologic literature. To review the use of the 1064 nm QS Nd:YAG laser for the treatment of argyria. A search of the National Library of Medicine's PubMed Database and the SCOPUS Database was performed to find articles that detailed the treatment of argyria with 1064 nm QS Nd:YAG laser. Six articles were selected for inclusion in this review. Each article was reviewed and summarized in a table. A 1064 nm QS Nd:YAG laser offers a novel and effective treatment for argyria. A systematic review of the dermatologic literature revealed a limited number of case reports and case series using this treatment. However, the results gleaned by the authors from the literature review provide important information to the clinician. For patients with argyria, a single pass of the 1064 nm QS Nd:YAG laser offers immediate, effective and sustained pigment clearing without any long-term adverse effects.
银沉着病是一种良性皮肤疾病，其特征为皮肤和/或黏膜中有银颗粒沉积导致的蓝至石板灰色变色。这种疾病是由于长期摄入离子化银溶液或暴露于空气中的银颗粒而引起的。皮肤变色可以是全身性的，也可以是局部性的，并且会因阳光照射而加重。皮肤变色通常是永久性的，直到最近，银沉着病还没有有效的治疗方法。在过去的 6 年中，一些病例报告和一个病例系列描述了使用 1064nm 调 Q（QS）钕掺杂钇铝石榴石（Nd：YAG）激光成功治疗银沉着病的病例；然而，这些研究的综述从未在皮肤科文献中报道过。本文旨在回顾 1064nmQS Nd：YAG 激光治疗银沉着病的应用。通过对美国国立医学图书馆的 PubMed 数据库和 SCOPUS 数据库进行检索，查找详细描述 1064nmQS Nd：YAG 激光治疗银沉着病的文章。选择了 6 篇文章纳入本综述。对每篇文章进行了综述和总结。1064nmQS Nd：YAG 激光为银沉着病提供了一种新颖而有效的治疗方法。对皮肤科文献的系统回顾显示，使用这种治疗方法的病例报告和病例系列数量有限。然而，作者从文献综述中得出的结果为临床医生提供了重要信息。对于银沉着病患者，单次使用 1064nmQS Nd：YAG 激光可立即、有效且持续地清除色素，无任何长期不良反应。
