Verlut C, Sylvestre G, Curtit E, Baron M-H, Medeiros De Bustos E, Moulin T, Magnin E
Service de neurologie, CHU de Besançon, 2, boulevard Fleming, 25030 Besançon, France; Service d'oncologie, CHU de Besançon, 2, boulevard Fleming, 25030 Besançon, France.
Service de neurologie, centre mémoire de ressources et de recherche, CHU de Besançon, 2, boulevard Fleming, 25030 Besançon, France.
Rev Neurol (Paris). 2015 Apr;171(4):382-9. doi: 10.1016/j.neurol.2015.02.009. Epub 2015 Apr 4.
Episodic memory disorders are frequent in patients with temporal lesion. Verbal or visuo-spatial memory disorders depend on the location and the lateralization of the lesion. These disorders are well described in temporal epilepsy but rarely in population with cerebral tumor and especially not specifically focus on temporal glioma. The purpose of this study was to describe neuropsychological examination in patient with temporal glioma in the database of the regional memory centre of Besançon. Four patients were identified (all right-handed and with a left temporal glioma). Verbal episodic memory impairment and auditory-verbal short-term memory impairment were observed. One patient had also visual memory disorders. Therefore, further investigations showed an associated Alzheimer's disease. This finding modified the clinical management of this patient. Extensive neuropsychological assessment should be systematic initially to seek an associated pathology, especially in elderly patients, if the cognitive profile is unusual, during the follow-up to better understand cognitive evolution and the effect of therapies on cognition.
发作性记忆障碍在颞叶病变患者中很常见。言语或视觉空间记忆障碍取决于病变的位置和侧别。这些障碍在颞叶癫痫中已有详细描述，但在脑肿瘤患者中很少见，尤其是没有专门针对颞叶胶质瘤的研究。本研究的目的是描述贝桑松地区记忆中心数据库中颞叶胶质瘤患者的神经心理学检查情况。共确定了4例患者（均为右利手且患有左侧颞叶胶质瘤）。观察到言语发作性记忆障碍和听觉言语短期记忆障碍。1例患者还存在视觉记忆障碍。进一步检查显示合并阿尔茨海默病。这一发现改变了该患者的临床管理。如果认知特征异常，最初应进行系统的广泛神经心理学评估以寻找相关病理情况，尤其是在老年患者中，在随访期间要更好地了解认知演变以及治疗对认知的影响。
