Noll Kyle R, Weinberg Jeffrey S, Ziu Mateo, Wefel Jeffrey S
Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Arch Clin Neuropsychol. 2016 Feb;31(1):37-46. doi: 10.1093/arclin/acv064. Epub 2015 Nov 3.
Recent research supports the utility of process variables in understanding mechanisms underlying memory impairments. The Hopkins Verbal Learning Test-Revised (HVLT-R) was administered to 84 patients with left (LTL, n = 58) or right temporal lobe glioma (RTL, n = 26) prior to surgical resection. Primary HVLT-R measures of learning and memory and numerous learning process indices were computed. Both groups exhibited frequent memory impairment (>30%), with greater severity in the LTL group. Patients with LTL glioma also exhibited lower semantic clustering scores than RTL patients, which were highly associated with Total Recall (ρ = 0.83) and Delayed Recall (ρ = 0.68). Learning slope and a novel measure of learning efficiency were also significantly associated with primary memory measures, though scores were similar across the LTL and RTL groups. While lesions to either temporal lobe impact verbal memory, semantic encoding appears to depend upon the integrity of LTL structures in particular.
近期研究支持过程变量在理解记忆障碍潜在机制方面的效用。在手术切除前，对84例左侧（左颞叶胶质瘤，n = 58）或右侧颞叶胶质瘤（右颞叶胶质瘤，n = 26）患者进行了霍普金斯词语学习测验修订版（HVLT-R）。计算了HVLT-R学习和记忆的主要指标以及众多学习过程指标。两组均表现出频繁的记忆障碍（>30%），左颞叶胶质瘤组更为严重。左颞叶胶质瘤患者的语义聚类得分也低于右颞叶胶质瘤患者，这与总回忆（ρ = 0.83）和延迟回忆（ρ = 0.68）高度相关。学习斜率和一种新的学习效率指标也与主要记忆指标显著相关，尽管左颞叶胶质瘤组和右颞叶胶质瘤组的得分相似。虽然任一颞叶的病变都会影响言语记忆，但语义编码似乎尤其依赖于左颞叶结构的完整性。
