Twigg Michael J, Wright David, Barton Garry R, Thornley Tracey, Kerr Clare
School of Pharmacy, Norwich, UK.
Health Economics Group, Norwich Medical School, University of East Anglia, Norwich, UK.
Int J Pharm Pract. 2015 Dec;23(6):407-14. doi: 10.1111/ijpp.12196. Epub 2015 Apr 6.
Inappropriate prescribing and nonadherence have a significant impact on hospital admissions and patient quality of life. The English government has identified that community pharmacy could make a significant contribution to reducing nonadherence and improving the quality of prescribing, reducing both hospital admissions and medicines wastage. The objective of this study is to evaluate a community pharmacy service aimed at patients over the age of 65 years prescribed four or more medicines.
Patients were invited to participate in the service by the community pharmacy team. The pharmacist held regular consultations with the patient and discussed risk of falls, pain management, adherence and general health. They also reviewed the patient's medication using STOPP/START criteria. Data were analysed for the first 6 months of participation in the service.
Six hundred twenty patients were recruited with 441 (71.1%) completing the 6-month study period. Pharmacists made 142 recommendations to prescribers in 110 patients largely centred on potentially inappropriate prescribing of NSAIDs, PPIs or duplication of therapy. At follow-up, there was a significant decrease in the total number of falls (mean -0.116 (-0.217--0.014)) experienced and a significant increase in medicine adherence (mean difference in Morisky Measure of Adherence Scale-8: 0.513 (0.337-0.689)) and quality of life. Cost per quality-adjusted life year estimates ranged from £11 885 to £32 466 depending on the assumptions made.
By focussing on patients over the age of 65 years with four or more medicines, community pharmacists can improve medicine adherence and patient quality of life.
不适当的处方开具和不依从对住院率和患者生活质量有重大影响。英国政府已明确,社区药房可在减少不依从和提高处方开具质量方面做出重大贡献,从而降低住院率和药品浪费。本研究的目的是评估一项针对65岁以上且正在服用四种或更多药物的患者的社区药房服务。
社区药房团队邀请患者参与该服务。药剂师定期与患者进行咨询,并讨论跌倒风险、疼痛管理、依从性和总体健康状况。他们还使用STOPP/START标准对患者的用药情况进行审查。对参与该服务的前6个月的数据进行了分析。
招募了620名患者,其中441名(71.1%)完成了为期6个月的研究期。药剂师向110名患者的处方医生提出了142条建议,主要集中在非甾体抗炎药、质子泵抑制剂的潜在不适当处方开具或治疗重复方面。在随访时,跌倒的总数显著减少(平均减少-0.116(-0.217--0.014)),药物依从性显著提高(Morisky依从性量表-8的平均差异:0.513(0.337-0.689)),生活质量也显著提高。根据所做的假设不同,每质量调整生命年的成本估计在11885英镑至32466英镑之间。
通过关注65岁以上且正在服用四种或更多药物的患者,社区药剂师可以提高药物依从性和患者生活质量。