通过萜烯合酶产生的新型嗅觉配体。
Novel olfactory ligands via terpene synthases.
作者信息
Touchet Sabrina, Chamberlain Keith, Woodcock Christine M, Miller David J, Birkett Michael A, Pickett John A, Allemann Rudolf K
机构信息
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
出版信息
Chem Commun (Camb). 2015 May 1;51(35):7550-3. doi: 10.1039/c5cc01814e.
A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.
一种合成生物学方法，通过为合成嗅觉配体（S）-吉马烯D（一种作为植物源昆虫驱避剂的嗅觉配体）的酶提供非天然底物，来合理设计嗅觉配体类似物以产生新型配体，被描述为在很大程度上不成功的配体对接研究的一种可行替代方法。（S）-14,15-二甲基吉马烯D在行为活性上表现出意外的反转。
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