Chen P J, Yang P M, Chen C R, Chen D S
Graduate Institute of Clinical Medicine, National Taiwan University Hospital, Taipei, Republic of China.
J Infect Dis. 1989 Dec;160(6):944-7. doi: 10.1093/infdis/160.6.944.
To examine the replication of hepatitis D virus (HDV) and its interactions with helper hepatitis B virus (HBV), the RNA of both viruses was analyzed in liver biopsy tissue obtained from six patients with past or present hepatitis. In four of five hepatitis B surface antigen (HBsAg) carriers, the RNA genome of HDV was found in the liver. Further, the complementary RNA species as replication templates of HDV genomes documented in previous animal studies were confirmed. Within the livers of four HBsAg carriers, the transcription of HBV was absent or incomplete, however, in the patient without HDV RNA, the HBV genes expressed accurately and actively. This may account for the previously observed HBV suppression by concomitant HDV infection.
为研究丁型肝炎病毒（HDV）的复制及其与辅助病毒乙型肝炎病毒（HBV）的相互作用，对6例曾患或现患肝炎患者的肝活检组织中的两种病毒RNA进行了分析。在5例乙型肝炎表面抗原（HBsAg）携带者中，有4例在肝脏中发现了HDV的RNA基因组。此外，先前动物研究中记录的作为HDV基因组复制模板的互补RNA种类也得到了证实。在4例HBsAg携带者的肝脏中，HBV转录缺失或不完整，然而，在没有HDV RNA的患者中，HBV基因准确且活跃地表达。这可能解释了先前观察到的HDV合并感染对HBV的抑制作用。
