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本文引用的文献

1
The Willingness to Pay for a Quality Adjusted Life Year: A Review of the Empirical Literature.支付意愿以获取质量调整生命年:实证文献综述。
Health Econ. 2015 Oct;24(10):1289-1301. doi: 10.1002/hec.3085. Epub 2014 Jul 28.
2
Total cost comparison in relapsed/refractory multiple myeloma.复发/难治性多发性骨髓瘤的总费用比较。
J Med Econ. 2013;16(5):614-22. doi: 10.3111/13696998.2012.760159. Epub 2013 Mar 19.
3
Early versus delayed autologous stem cell transplant in patients receiving novel therapies for multiple myeloma.新型疗法治疗多发性骨髓瘤患者中早期与延迟自体干细胞移植的比较。
Leuk Lymphoma. 2013 Aug;54(8):1658-64. doi: 10.3109/10428194.2012.751528. Epub 2012 Dec 31.
4
Lenalidomide for multiple myeloma: cost-effectiveness in patients with one prior therapy in England and Wales.来那度胺治疗多发性骨髓瘤:在英格兰和威尔士有一次既往治疗的患者中的成本效益。
Eur J Health Econ. 2013 Jun;14(3):507-14. doi: 10.1007/s10198-012-0395-6. Epub 2012 May 10.
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Multiple myeloma.多发性骨髓瘤
Lancet. 2009 Jul 25;374(9686):324-39. doi: 10.1016/S0140-6736(09)60221-X. Epub 2009 Jun 21.
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Cost of care for elderly cancer patients in the United States.美国老年癌症患者的护理费用。
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7
A 1-year double-blind study of 2 doses of long-acting risperidone in stable patients with schizophrenia or schizoaffective disorder.一项针对精神分裂症或分裂情感性障碍稳定期患者使用两种剂量长效利培酮的为期1年的双盲研究。
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质量调整后的护理成本:衡量创新成本增长与健康收益价值的一种有意义的方式。

Quality-adjusted cost of care: a meaningful way to measure growth in innovation cost versus the value of health gains.

作者信息

Lakdawalla Darius, Shafrin Jason, Lucarelli Claudio, Nicholson Sean, Khan Zeba M, Philipson Tomas J

机构信息

Darius Lakdawalla (

Jason Shafrin is a senior research economist at Precision Health Economics, in Los Angeles.

出版信息

Health Aff (Millwood). 2015 Apr;34(4):555-61. doi: 10.1377/hlthaff.2014.0639.

DOI:10.1377/hlthaff.2014.0639
PMID:25847636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4406284/
Abstract

Technology drives both health care spending and health improvement. Yet policy makers rarely see measures of cost growth that account for both effects. To fill this gap, we present the quality-adjusted cost of care, which illustrates cost growth net of growth in the value of health improvements, measured as survival gains multiplied by the value of survival. We applied the quality-adjusted cost of care to two cases. For colorectal cancer, drug cost per patient increased by $34,493 between 1998 and 2005 as a result of new drug launches, but value from offsetting health improvements netted a modest $1,377 increase in quality-adjusted cost of care. For multiple myeloma, new therapies increased treatment cost by $72,937 between 2004 and 2009, but offsetting health benefits lowered overall quality-adjusted cost of care by $67,863. However, patients with multiple myeloma on established first-line therapies saw costs rise without corresponding benefits. All three examples document rapid cost growth, but they provide starkly different answers to the question of whether society got what it paid for.

摘要

技术推动了医疗保健支出和健康改善。然而,政策制定者很少看到能兼顾这两种影响的成本增长衡量指标。为了填补这一空白,我们提出了质量调整后的护理成本,它说明了扣除健康改善价值增长后的成本增长情况,健康改善价值增长以生存收益乘以生存价值来衡量。我们将质量调整后的护理成本应用于两个案例。对于结直肠癌,由于新药上市,1998年至2005年间每位患者的药物成本增加了34,493美元,但抵消健康改善带来的价值后,质量调整后的护理成本仅适度增加了1,377美元。对于多发性骨髓瘤,2004年至2009年间新疗法使治疗成本增加了72,937美元,但抵消健康益处后,总体质量调整后的护理成本降低了67,863美元。然而,接受既定一线疗法的多发性骨髓瘤患者的成本上升了,却没有相应的益处。所有这三个例子都表明成本增长迅速,但对于社会是否物有所值这个问题,它们给出了截然不同的答案。