Hajoui Fatima Zahra, Biaz Asmaa, Zouiten Lamyaa, Mechtani Samira, Dami Abdellah, Bouhsain Sanaa, Ouzzif Zohra
Service de biochimie, Hôpital militaire d'instruction Mohamed V (HMIMV), Rabat, Maroc, Université Mohamed V Souissi, Faculté de médicine et de pharmacie Rabat, Maroc.
Ann Biol Clin (Paris). 2015 Mar-Apr;73(2):190-4. doi: 10.1684/abc.2015.1028.
Bisalbuminemia whether hereditary or acquired, is a rare electrophoretic abnormality of albumin, characterized by a duplication of the albumin fraction on the electrophoretic trace of the serum proteins. This duplication reflects the presence in the same individual normal plasma albumin and a modified albumin.
This is a patient of 62 years hospitalized at the Internal Medicine Department of HMIMV for liver metastases of gastrointestinal adenocarcinoma and including serum protein electrophoresis (EP) performed on capillary (Capillarys society Sebia) reveals bisalbuminemia. The family investigation has ruled that inheritance of acquired bisalbuminemia to retain appearance.
Bisalbuminemia acquired outside treatment with high doses of beta-lactam antibiotics, chronic pancreatitis with pseudocyst rupture or fixing a monoclonal immunoglobulin on albumin in the myeloma subjects is an exceptional event. The pathophysiologic mechanism in the reported cases remains unexplained as is also the case of acquired bisalbuminemias associated with other pathological contexts (Alzheimer's disease nephrotic syndrome).
To the best of our knowledge, the bisalbuminemia in the gastrointestinal adenocarcinoma liver metastases has not been reported to date, hence the importance of the reported cases.
双白蛋白血症无论是遗传性的还是后天获得性的，都是一种罕见的白蛋白电泳异常，其特征是血清蛋白电泳图谱上白蛋白部分出现重复。这种重复反映了同一个体中正常血浆白蛋白和一种修饰白蛋白的存在。
这是一名62岁的患者，因胃肠道腺癌肝转移入住HMIMV内科，其毛细管血清蛋白电泳（Capillarys公司，赛比娅）显示双白蛋白血症。家族调查排除了后天性双白蛋白血症的遗传因素，以保留其表现。
在未接受高剂量β-内酰胺类抗生素治疗、慢性胰腺炎伴假性囊肿破裂或骨髓瘤患者中白蛋白固定单克隆免疫球蛋白的情况下获得性双白蛋白血症是一个例外事件。报告病例中的病理生理机制仍未得到解释，与其他病理情况（阿尔茨海默病、肾病综合征）相关的后天性双白蛋白血症也是如此。
据我们所知，胃肠道腺癌肝转移中的双白蛋白血症迄今尚未见报道，因此所报告病例具有重要意义。
