[双白蛋白血症：一例报告]
[Bisalbuminemia: A case report].
作者信息
Lefrère B, Dedôme E, Garcia-Hejl C, Ragot C, Chianea D, Delacour H, Cremades S, Vest P
机构信息
Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.
Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.
出版信息
Rev Med Interne. 2018 Dec;39(12):950-954. doi: 10.1016/j.revmed.2018.05.010. Epub 2018 Jun 18.
INTRODUCTION
Bisalbuminemias consist in rare qualitative modifications of several aspects in the albumin pattern. Bisalbuminemias, most of which are not pathological, can be observed using capillary electrophoresis.
CASE REPORTS
We report a case of hereditary bisalbuminemia diagnosed by chance while exploring chronic unexplained hypereosinophilia in a 42-year-old patient. The patient's normal lipid profile, the lack of an antibiotic treatment or pancreatic pathology, and the persistence of the bisalbuminemia after one month, suggested a diagnosis of genetic bisalbuminemia. In light of other such cases, we review the main causes of bisalbuminemia, both genetic and acquired.
CONCLUSION
The diagnosis of genetic bisalbuminemia is made by first eliminating the usual acquired etiologies: analytical or drug interference, acute pancreatitis and binding of immunoglobulins. Then, after having checked the lipemic index, reviewed the patient's medical history, comorbidities, and treatments, repeating the electrophoresis will help identify the cause of the bisalbuminemia.
引言
双白蛋白血症表现为白蛋白图谱在多个方面的罕见质性改变。多数双白蛋白血症并无病理性，可通过毛细管电泳观察到。
病例报告
我们报告一例遗传性双白蛋白血症病例，该病例是在对一名42岁患者慢性不明原因嗜酸性粒细胞增多症进行检查时偶然诊断出的。患者血脂谱正常，无抗生素治疗史或胰腺病变，且双白蛋白血症持续一个月，提示遗传性双白蛋白血症的诊断。结合其他此类病例，我们回顾了双白蛋白血症的主要病因，包括遗传和后天性病因。
结论
遗传性双白蛋白血症的诊断首先要排除常见的后天性病因：分析或药物干扰、急性胰腺炎以及免疫球蛋白结合。然后，在检查血脂指数、回顾患者病史、合并症和治疗情况后，重复进行电泳将有助于确定双白蛋白血症的病因。
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