Inokuchi Naoki, Ikeda Tsunehiko, Nakamura Kimitoshi, Morishita Seita, Fukumoto Masanori, Kida Teruyo, Oku Hidehiro
Inokuchi Eye Clinic, Suita-City Osaka, Japan.
Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
Clin Ophthalmol. 2015 Mar 20;9:549-52. doi: 10.2147/OPTH.S80754. eCollection 2015.
Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).
Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count(®) Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.
The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).
The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.
雌激素作为一种女性激素，可激活胶原酶，可能与玻璃体视网膜胶原纤维疾病的发病机制有关。本研究的目的是调查特发性黄斑裂孔（IMH）患者玻璃体内雌酮（E1）和雌二醇（E2）的水平。
在玻璃体手术时，从10例患有IMH的女性患者以及9例患有其他视网膜疾病的女性患者（6例孔源性视网膜脱离和3例年龄相关性黄斑变性）中获取玻璃体样本作为对照。然后分别使用Coat-A-Count®雌二醇放射免疫分析（RIA）试剂盒和DSL-70雌酮RIA试剂盒测定玻璃体样本中的E1和E2水平。
IMH患者玻璃体内E1和E2的平均水平分别为1.83±2.00 pg/mL和7.03±2.97 pg/mL，而对照患者分别为2.42±1.25 pg/mL和4.90±2.90 pg/mL。因此，IMH患者的玻璃体内E2水平显著高于对照组（P<0.05）。
本研究结果表明E2可能与IMH的发病机制有关，但需要进一步研究以阐明这种关联。
