乙型肝炎病毒基因组的变异与突变及其与临床特征的关联。
Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics.
作者信息
Yano Yoshihiko, Azuma Takeshi, Hayashi Yoshitake
机构信息
Yoshihiko Yano, Takeshi Azuma, Department of Gastroenterology, Kobe University Graduate School of Medicine, Kusunoki-cho, Kobe 650-0017, Japan.
出版信息
World J Hepatol. 2015 Mar 27;7(3):583-92. doi: 10.4254/wjh.v7.i3.583.
Abstract
Hepatitis B virus (HBV) infection is major global issue, because chronic HBV infection is strongly associated with liver cancer. HBV spread worldwide with various mutations and variations. This variability, called quasispecies, is derived from no proof-reading capacity of viral reverse transcriptase. So far, thousands of studies reported that the variety of genome is closely related to the geographic distribution and clinical characteristics. Recent technological advances including capillary sequencer and next generation sequencer have made in easier to analyze mutations. The variety of HBV genome is related to not only antigenicity of HBs-antigen but also resistance to antiviral therapies. Understanding of these variations is important for the development of diagnostic tools and the appropriate therapy for chronic hepatitis B. In this review, recent publications in relation to HBV mutations and variations are updated and summarized.
摘要
乙型肝炎病毒（HBV）感染是一个重大的全球性问题，因为慢性HBV感染与肝癌密切相关。HBV通过各种突变和变异在全球传播。这种变异性，即所谓的准种，源于病毒逆转录酶缺乏校对能力。到目前为止，数千项研究报告称，基因组的多样性与地理分布和临床特征密切相关。包括毛细管测序仪和下一代测序仪在内的最新技术进展使分析突变变得更加容易。HBV基因组的多样性不仅与乙肝表面抗原（HBs抗原）的抗原性有关，还与对抗病毒治疗的耐药性有关。了解这些变异对于开发诊断工具和慢性乙型肝炎的适当治疗非常重要。在这篇综述中，对近期有关HBV突变和变异的出版物进行了更新和总结。
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