Suk Ki Tae, Kim Dong Joon
Ki Tae Suk, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
World J Hepatol. 2015 Mar 27;7(3):607-15. doi: 10.4254/wjh.v7.i3.607.
Liver fibrosis is a common histological change of chronic liver injury and it is closely related with portal hypertension which is hemodynamic complication of chronic liver disease. Currently, liver fibrosis has been known as a reversible dynamic process in previous literatures. Although liver biopsy is a gold standard for assessing the stage of liver fibrosis, it may not completely represent the stage of liver fibrosis because of sampling error or semi-quantative measurement. Recent evidences suggested that histologic, clinical, hemodynamic, and biologic features are closely associated in patients with chronic liver disease. Hepatic venous pressure gradient (HVPG) measurement has been known as a modality to evaluate the portal pressure. The HVPG measurement has been used clinically for fibrosis diagnosis, risk stratification, preoperative screening for liver resection, monitoring the efficacy of medical treatments, and assessing the prognosis of liver fibrosis. Therefore, the HVPG measurement can be used to monitor areas the chronic liver disease but also other important areas of chronic liver disease.
肝纤维化是慢性肝损伤常见的组织学变化，它与门静脉高压密切相关，门静脉高压是慢性肝病的血流动力学并发症。目前，在以往文献中肝纤维化已被认为是一个可逆的动态过程。尽管肝活检是评估肝纤维化阶段的金标准，但由于抽样误差或半定量测量，它可能无法完全代表肝纤维化的阶段。最近的证据表明，慢性肝病患者的组织学、临床、血流动力学和生物学特征密切相关。肝静脉压力梯度（HVPG）测量已被认为是评估门静脉压力的一种方法。HVPG测量已在临床上用于纤维化诊断、风险分层、肝切除术前筛查、监测药物治疗效果以及评估肝纤维化的预后。因此，HVPG测量不仅可用于监测慢性肝病的相关领域，还可用于监测慢性肝病的其他重要领域。
