Mansouri Rafik, Haÿ Eric, Marie Pierre J, Modrowski Dominique
UMR-1132, Bone and Cartilage Biology, INSERM and University Paris Diderot, Sorbonne Paris Cité , Paris, France.
Bonekey Rep. 2015 Apr 1;4:666. doi: 10.1038/bonekey.2015.33. eCollection 2015.
Syndecans 1-4 are a family of transmembrane proteins composed of a core protein and glycosaminoglycan chains. Although the four syndecans have common functions, they appear to be connected to different signaling pathways, and their expression occurs in a cell- and development-specific pattern. In contrast to other syndecans, syndecan-2 expression increases during osteoblast differentiation. Mechanistically, syndecan-2 exerts multiple functions in cells of the osteoblast lineage as it serves as a co-receptor for fibroblast growth factors and Wnt proteins and controls cell adhesion, proliferation, differentiation and apoptosis. Recent studies indicate that syndecan-2 also contributes to osteosarcoma cell response to cytotoxic agents through interactions with Wnt/β-catenin signaling. Here we summarize our current understanding of the role of syndecan-2 in the control of osteoblast biology and pathology and discuss how syndecan-2 acts as a modulator of the bone cell microenvironment.
Syndecans 1 - 4是一类跨膜蛋白家族，由核心蛋白和糖胺聚糖链组成。尽管这四种Syndecans具有共同功能，但它们似乎与不同的信号通路相关联，并且其表达呈现细胞和发育特异性模式。与其他Syndecans不同，Syndecan - 2在成骨细胞分化过程中表达增加。从机制上讲，Syndecan - 2在成骨细胞谱系的细胞中发挥多种功能，因为它作为成纤维细胞生长因子和Wnt蛋白的共受体，并控制细胞黏附、增殖、分化和凋亡。最近的研究表明，Syndecan - 2还通过与Wnt/β - 连环蛋白信号通路相互作用，促进骨肉瘤细胞对细胞毒性药物的反应。在此，我们总结了目前对Syndecan - 2在成骨细胞生物学和病理学控制中的作用的理解，并讨论了Syndecan - 2如何作为骨细胞微环境的调节因子发挥作用。
