从药丸到患者：评估德国接受抗逆转录病毒治疗的艾滋病毒感染者人数的数据来源

From pills to patients: an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in Germany.

作者信息

Schmidt Daniel, Kollan Christian, Stoll Matthias, Stellbrink Hans-Jürgen, Plettenberg Andreas, Fätkenheuer Gerd, Bergmann Frank, Bogner Johannes R, van Lunzen Jan, Rockstroh Jürgen, Esser Stefan, Jensen Björn-Erik Ole, Horst Heinz-August, Fritzsche Carlos, Kühne Andrea, an der Heiden Matthias, Hamouda Osamah, Bartmeyer Barbara

出版信息

BMC Public Health. 2015 Mar 17;15:252. doi: 10.1186/s12889-015-1598-4.

BACKGROUND

This study aimed to determine the number of people living with HIV receiving antiretroviral therapy (ART) between 2006 and 2013 in Germany by using the available numbers of antiretroviral drug prescriptions and treatment data from the ClinSurv HIV cohort (CSH).

METHODS

The CSH is a multi-centre, open, long-term observational cohort study with an average number of 10.400 patients in the study period 2006-2013. ART has been documented on average for 86% of those CSH patients and medication history is well documented in the CSH.

RESULTS

The proportion of CSH patients receiving TCMs increased continuously over time (from 85% to 93%; 2006-2013). In contrast, treatment interruptions declined remarkably (from 11% to 2%; 2006-2013). The total number of HIV-infected people with ART experience in Germany increased from 31,500 (95% CI 31,000-32,000) individuals to 54,000 (95% CI 53,000-55,500) over the observation period (including 16.3% without SHI and persons who had interrupted ART). An average increase of approximately 2,900 persons receiving ART was observed annually in Germany.

CONCLUSIONS

A substantial increase in the number of people receiving ART was observed from 2006 to 2013 in Germany.

背景

本研究旨在利用抗逆转录病毒药物处方的可用数量以及ClinSurv HIV队列（CSH）的治疗数据，确定2006年至2013年期间德国接受抗逆转录病毒治疗（ART）的艾滋病毒感染者人数。

方法

CSH是一项多中心、开放性、长期观察性队列研究，在2006 - 2013年研究期间平均有10400名患者。这些CSH患者中平均86%有ART记录，且CSH中用药史记录良好。

结果

接受ART的CSH患者比例随时间持续增加（从85%增至93%；2006 - 2013年）。相比之下，治疗中断显著下降（从11%降至2%；2006 - 2013年）。在观察期内，德国有ART治疗经历的艾滋病毒感染者总数从31500人（95%置信区间31000 - 32000）增至54000人（95%置信区间53000 - 55500）（包括16.3%无法定医疗保险和中断ART治疗的人）。德国每年接受ART治疗的人数平均增加约2900人。