Vayssairat M, Blaison N, Baudot N, Evenou P, Gilard M, Mathieu J F
Service de Médecine IV, Hôpital Broussais, Paris.
J Mal Vasc. 1989;14(4):299-302.
To determine the effects of Nifedipine on cold stress reactive hyperemia in patients with Raynaud's phenomenon.
Open trial comprising an observation period without treatment and a treatment period with Nifedipine.
Referral-based angiology department in a university hospital.
26 patients with definite Raynaud's phenomenon were included; 6 patients were withdrawn (3 for side effects, 1 for pregnancy, 2 for protocol inobservance). INTERVENTIONS took place after one week of observation and one week of treatment with Nifedipine per os 20 mg 3 times daily. At day 0, 7 and 14, cold stress was performed to measure cold reactive post-ischemic hyperemia.
During the Nifedipine period, the number of attacks, their intensity and resulting total disability decreased significantly, and hyperemia increased significantly.
Our study confirms improvement in Raynaud's phenomenon with Nifedipine. This calcium-channel inhibitory drug also improves cold reactive hyperemia. This new cold test is inexpensive and easy to perform and appears to be suitable for assessing hemodynamic objective improvement in drug trials concerning Raynaud's phenomenon.
确定硝苯地平对雷诺现象患者冷应激反应性充血的影响。
开放性试验，包括无治疗的观察期和使用硝苯地平的治疗期。
大学医院中基于转诊的血管病科。
纳入26例确诊为雷诺现象的患者；6例退出研究（3例因副作用，1例因妊娠，2例因未遵守方案）。在观察一周和口服硝苯地平20毫克每日3次治疗一周后进行干预。在第0天、第7天和第14天，进行冷应激以测量冷反应性缺血后充血情况。
在硝苯地平治疗期间，发作次数、发作强度及由此导致的总体残疾程度显著降低，充血情况显著增加。
我们的研究证实硝苯地平可改善雷诺现象。这种钙通道抑制药物还可改善冷反应性充血。这种新的冷试验价格低廉且易于实施，似乎适用于评估有关雷诺现象的药物试验中血液动力学的客观改善情况。
