Wigley F M, Malamet R, Wise R A
Department of Medicine, Johns Hopkins Medical Institutions, Francis Scott Key Medical Center, Baltimore, MD 21224.
J Rheumatol. 1987 Aug;14(4):751-5.
Twenty-five patients with Raynaud's phenomenon had serial cold challenges during a double blinded drug trial. The data were analyzed to determine the reproducibility of cold provocation in the induction of critical closure of the digital artery in patients with Raynaud's phenomenon. Finger systolic pressure (FSP) was measured after local digital cooling using a digital strain gauge placed around the distal phalanx. Nineteen of 25 patients completed the study. The prevalence of inducing a Raynaud's attack decreased with each successive cold challenge from 74% of patients at initial challenge to 42% at the 3rd challenge. A lower temperature was required to induce a Raynaud's attack at last challenge (10.6 +/- 0.6 degrees C) compared to the first cold challenge (13.2 +/- 1.0 degrees C). Our data demonstrate adaptation to a laboratory cold challenge through the winter months in patients with Raynaud's phenomenon and show it is an important factor in objectively assessing drug efficacy in the treatment of Raynaud's phenomenon.
在一项双盲药物试验中，25名患有雷诺现象的患者接受了一系列冷刺激试验。对数据进行分析，以确定在患有雷诺现象的患者中，冷激发试验诱导指动脉临界闭合的可重复性。使用置于远端指骨周围的数字应变仪在局部手指冷却后测量手指收缩压（FSP）。25名患者中有19名完成了研究。诱发雷诺发作的发生率在每次连续冷刺激试验中逐渐降低，从初次刺激时74%的患者降至第三次刺激时的42%。与第一次冷刺激试验（13.2±1.0℃）相比，最后一次刺激试验（10.6±0.6℃）诱发雷诺发作所需的温度更低。我们的数据表明，患有雷诺现象的患者在冬季几个月中对实验室冷刺激试验产生了适应性，并且表明这是客观评估治疗雷诺现象药物疗效的一个重要因素。
