Cieplik Jerzy, Stolarczyk Marcin, Pluta Janusz, Gubrynowicz Olaf, Bryndal Iwona, Lis Tadeusz, Mikulewicz Marcin
Acta Pol Pharm. 2015 Jan-Feb;72(1):53-64.
In this study, a series of syntheses was conducted on the pyrimidine system, obtaining bisulfite carboxyl derivatives 4 and hydroxy derivatives 5. In addition, a series of syntheses were carried out as a result of which both alkyl and aromatic amines were obtained. Then, the attempt was made to cyclize these amines in the Mannich reaction to pyrimido[4,5-d]pyrimidines 11, 12. After determination of chemical structure using physicochemical tests, also by means of crystallographic tests, all the newly obtained derivatives underwent microbiological tests on bacterial strains and fungi. The most interesting results of the microbiological tests are included later in the study.
在本研究中，对嘧啶体系进行了一系列合成，得到了亚硫酸氢盐羧基衍生物4和羟基衍生物5。此外，还进行了一系列合成，由此得到了烷基胺和芳香胺。然后，尝试在曼尼希反应中将这些胺环化生成嘧啶并[4,5 - d]嘧啶11、12。在使用物理化学测试以及晶体学测试确定化学结构之后，所有新得到的衍生物都针对细菌菌株和真菌进行了微生物测试。微生物测试中最有趣的结果将在本研究后面部分呈现。
