衰老与肝脏疾病。
Aging and liver disease.
作者信息
Kim In Hee, Kisseleva Tatiana, Brenner David A
机构信息
aDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea bDepartment of Internal Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.
出版信息
Curr Opin Gastroenterol. 2015 May;31(3):184-91. doi: 10.1097/MOG.0000000000000176.
PURPOSE OF REVIEW
Aging is a condition in which a person gradually loses the ability to maintain homeostasis, due to structural alteration or dysfunction. Aging is a major risk factor for most chronic diseases. As the liver has a remarkable ability to regenerate, this review assessed the effect of aging on clinical liver disease with references to preclinical models when relevant to pathogenesis.
RECENT FINDINGS
Aging has been shown to not only enhance vulnerability to acute liver injury but also increase susceptibility of the fibrotic response. Aging is associated with the severity and poor prognosis of various liver diseases including nonalcoholic fatty liver disease, alcoholic liver disease, hepatitis C, and liver transplantation.
SUMMARY
Treatment of older patients with liver disease may require different or longer interventions. Transplantation of an older liver will be less tolerant of subsequent injury. Future studies are needed to understand more about the molecular mechanism of aging and contribute to the development of a noble treatment strategy that can block the progression of aging-induced liver diseases.
综述目的
衰老是一种由于结构改变或功能障碍导致个体逐渐丧失维持体内平衡能力的状态。衰老是大多数慢性疾病的主要危险因素。由于肝脏具有显著的再生能力，本综述在与发病机制相关时，参考临床前模型评估了衰老对临床肝病的影响。
最新发现
衰老不仅已被证明会增加对急性肝损伤的易感性，还会增强纤维化反应的易感性。衰老与包括非酒精性脂肪性肝病、酒精性肝病、丙型肝炎和肝移植在内的各种肝病的严重程度及不良预后相关。
总结
老年肝病患者的治疗可能需要不同的或更长时间的干预措施。老年肝脏移植对后续损伤的耐受性较低。需要进一步的研究以更深入了解衰老的分子机制，并有助于开发一种能够阻止衰老诱导的肝病进展的新型治疗策略。
Zotero 插件