Poliacikova Gabriela, Maurel-Zaffran Corinne, Graba Yacine, Saurin Andrew J
Aix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
Front Cell Dev Biol. 2021 Oct 18;9:731996. doi: 10.3389/fcell.2021.731996. eCollection 2021.
Hox genes encode evolutionary conserved transcription factors that specify the anterior-posterior axis in all bilaterians. Being well known for their role in patterning ectoderm-derivatives, such as CNS and spinal cord, Hox protein function is also crucial in mesodermal patterning. While well described in the case of the vertebrate skeleton, much less is known about Hox functions in the development of different muscle types. In contrast to vertebrates however, studies in the fruit fly, , have provided precious insights into the requirement of Hox at multiple stages of the myogenic process. Here, we provide a comprehensive overview of Hox protein function in and vertebrate muscle development, with a focus on the molecular mechanisms underlying target gene regulation in this process. Emphasizing a tight ectoderm/mesoderm cross talk for proper locomotion, we discuss shared principles between CNS and muscle lineage specification and the emerging role of Hox in neuromuscular circuit establishment.
Hox基因编码进化保守的转录因子，这些转录因子决定了所有两侧对称动物的前后轴。Hox蛋白以其在诸如中枢神经系统和脊髓等外胚层衍生物的模式形成中的作用而闻名，其功能在中胚层模式形成中也至关重要。虽然在脊椎动物骨骼的情况下已有详细描述，但对于Hox在不同肌肉类型发育中的功能了解较少。然而，与脊椎动物不同的是，对果蝇的研究为Hox在成肌过程多个阶段的需求提供了宝贵的见解。在这里，我们全面概述了Hox蛋白在果蝇和脊椎动物肌肉发育中的功能，重点关注这一过程中靶基因调控的分子机制。强调外胚层/中胚层之间紧密的相互作用对于正常运动的重要性，我们讨论了中枢神经系统和肌肉谱系特化之间的共同原则以及Hox在神经肌肉回路建立中的新作用。
