Sharma Prem Prakash, Rathi Brijesh, Rodrigues Joao, Gorobets Nikolay Yu
Department of Chemistry of Heterocyclic Compounds, State Scientific Institution "Institute for Single Crystals", National Academy of Science of Ukraine, Leninaave. 60, Kharkiv, 61001, Ukraine.
Curr Top Med Chem. 2015;15(13):1268-89. doi: 10.2174/1568026615666150408105711.
Among the diversity of natural and synthetic compounds being studied and applied for human welfare, peptides able to develop nanostructures are currently under special attention of scientists. In this review, we focus on such properties of peptides and various kinds of intramolecular interactions allowing their ability to form different shapes of nanoassemblies. We have also discussed the applications of self-assembled peptides in various biomedical fields where they can be employed as cargo to target delivery of drugs, genes, in tissue engineering, regenerative medicines, and biosensors.
在为人类福祉而研究和应用的天然和合成化合物的多样性中,能够形成纳米结构的肽目前受到科学家的特别关注。在这篇综述中,我们关注肽的此类特性以及各种分子内相互作用,这些相互作用使它们能够形成不同形状的纳米聚集体。我们还讨论了自组装肽在各种生物医学领域的应用,在这些领域中它们可以用作载体,用于药物、基因的靶向递送,以及用于组织工程、再生医学和生物传感器。