Martin Isabella W, Martin Christi-Lynn B, Dunbar Nancy M, Lee Stephen L, Szczepiorkowski Zbigniew M
Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
J Clin Apher. 2016 Feb;31(1):63-5. doi: 10.1002/jca.21395. Epub 2015 Apr 7.
Autoantibodies to the voltage-gated potassium channel (VGKC) complex cause a spectrum of non-paraneoplastic neurologic syndromes including limbic encephalitis (LE). We report a case of a man with LE who underwent a course of therapeutic plasma exchange (TPE) in addition to other immunomodulatory therapies and experienced sustained clinical resolution of his symptoms. This report adds to the existing literature supporting TPE in cases of LE due to VGKC complex autoantibodies.
针对电压门控钾通道（VGKC）复合物的自身抗体可引发一系列非副肿瘤性神经综合征，包括边缘叶脑炎（LE）。我们报告了一例患有边缘叶脑炎的男性患者，除接受其他免疫调节治疗外，还接受了一个疗程的治疗性血浆置换（TPE），其症状得到了持续的临床缓解。本报告补充了现有文献，支持在因VGKC复合物自身抗体导致的边缘叶脑炎病例中使用治疗性血浆置换。
