Huang Tao, Qi Qibin, Zheng Yan, Ley Sylvia H, Manson JoAnn E, Hu Frank B, Qi Lu
Department of Nutrition, Harvard School of Public Health, Boston, MA.
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Diabetes Care. 2015 Jul;38(7):1306-11. doi: 10.2337/dc14-3084. Epub 2015 Apr 7.
Abdominal obesity is a major risk factor for type 2 diabetes (T2D). We aimed to examine the association between the genetic predisposition to central obesity, assessed by the waist-to-hip ratio (WHR) genetic score, and T2D risk.
The current study included 2,591 participants with T2D and 3,052 participants without T2D of European ancestry from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Genetic predisposition to central obesity was estimated using a genetic score based on 14 established loci for the WHR.
We found that the central obesity genetic score was linearly related to higher T2D risk. Results were similar in the NHS (women) and HPFS (men). In combined results, each point of the central obesity genetic score was associated with an odds ratio (OR) of 1.04 (95% CI 1.01-1.07) for developing T2D, and the OR was 1.24 (1.03-1.45) when comparing extreme quartiles of the genetic score after multivariate adjustment.
The data indicate that genetic predisposition to central obesity is associated with higher T2D risk. This association is mediated by central obesity.
腹部肥胖是2型糖尿病（T2D）的主要危险因素。我们旨在研究通过腰臀比（WHR）遗传评分评估的中心性肥胖遗传易感性与T2D风险之间的关联。
本研究纳入了来自护士健康研究（NHS）和卫生专业人员随访研究（HPFS）的2591名患有T2D的欧洲血统参与者和3052名未患T2D的参与者。使用基于14个已确定的WHR基因座的遗传评分来估计中心性肥胖的遗传易感性。
我们发现中心性肥胖遗传评分与较高的T2D风险呈线性相关。在NHS（女性）和HPFS（男性）中的结果相似。综合结果显示，中心性肥胖遗传评分的每增加一分与发生T2D的比值比（OR）为1.04（95%可信区间1.01 - 1.07）相关，在多变量调整后比较遗传评分的极端四分位数时，OR为1.24（1.03 - 1.45）。
数据表明中心性肥胖的遗传易感性与较高的T2D风险相关。这种关联由中心性肥胖介导。
