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Could vagus nerve stimulation target hippocampal hyperactivity to improve cognition in schizophrenia?

作者信息

Smucny Jason, Visani Adrienne, Tregellas Jason R

机构信息

Neuroscience Program, University of Colorado Anschutz Medical Campus , Aurora, CO , USA ; Research Service, Denver Veterans Affairs Medical Center , Denver, CO , USA ; Department of Psychiatry, University of Colorado Anschutz Medical Campus , Aurora, CO , USA.

Department of Psychiatry, University of Colorado Anschutz Medical Campus , Aurora, CO , USA.

出版信息

Front Psychiatry. 2015 Mar 24;6:43. doi: 10.3389/fpsyt.2015.00043. eCollection 2015.

DOI:10.3389/fpsyt.2015.00043
PMID:25852579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4371554/
Abstract
摘要

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Could vagus nerve stimulation target hippocampal hyperactivity to improve cognition in schizophrenia?迷走神经刺激能否针对海马体过度活跃来改善精神分裂症患者的认知功能？
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本文引用的文献

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Non-invasive Access to the Vagus Nerve Central Projections via Electrical Stimulation of the External Ear: fMRI Evidence in Humans.通过电刺激外耳对迷走神经中枢投射进行非侵入性通路研究：人类功能磁共振成像证据
Brain Stimul. 2015 May-Jun;8(3):624-36. doi: 10.1016/j.brs.2014.11.018. Epub 2014 Dec 6.
2
Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals.胍法辛可增强早期戒毒的可卡因依赖个体的抑制控制和注意力转移能力。
J Psychopharmacol. 2015 Mar;29(3):312-23. doi: 10.1177/0269881114562464. Epub 2015 Jan 7.
3
GABAergic mechanisms of hippocampal hyperactivity in schizophrenia.精神分裂症中海马体活动亢进的γ-氨基丁酸能机制
Schizophr Res. 2015 Sep;167(1-3):4-11. doi: 10.1016/j.schres.2014.09.041. Epub 2014 Oct 18.
4
The effect of transcutaneous vagus nerve stimulation on cortical excitability.经皮迷走神经刺激对皮质兴奋性的影响。
J Neural Transm (Vienna). 2015 May;122(5):679-85. doi: 10.1007/s00702-014-1299-7. Epub 2014 Sep 3.
5
Guanfacine for attention deficit and hyperactivity disorder in pediatrics: a systematic review and meta-analysis.胍法辛治疗儿科注意缺陷多动障碍的系统评价和 Meta 分析。
Eur Neuropsychopharmacol. 2014 Oct;24(10):1578-90. doi: 10.1016/j.euroneuro.2014.08.001. Epub 2014 Aug 11.
6
Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia.迷走神经刺激可逆转甲基苯丙胺乙酸盐啮齿动物精神分裂症模型中异常的多巴胺系统功能。
J Neurosci. 2014 Jul 9;34(28):9261-7. doi: 10.1523/JNEUROSCI.0588-14.2014.
7
Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?迷走神经刺激……25年后！我们对其对认知的影响了解多少？
Neurosci Biobehav Rev. 2014 Sep;45:63-71. doi: 10.1016/j.neubiorev.2014.05.005. Epub 2014 May 21.
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Merging old and new perspectives on nicotinic acetylcholine receptors.融合烟碱型乙酰胆碱受体的新旧观点。
Biochem Pharmacol. 2014 May 1;89(1):1-11. doi: 10.1016/j.bcp.2014.01.029. Epub 2014 Jan 31.
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Intrinsic hippocampal activity as a biomarker for cognition and symptoms in schizophrenia.内源性海马活动作为精神分裂症认知和症状的生物标志物。
Am J Psychiatry. 2014 May;171(5):549-56. doi: 10.1176/appi.ajp.2013.13070981.
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Improving cognition in schizophrenia with antipsychotics that elicit neurogenesis through 5-HT(1A) receptor activation.使用通过激活5-HT(1A)受体引发神经发生的抗精神病药物改善精神分裂症患者的认知功能。
Neurobiol Learn Mem. 2014 Apr;110:72-80. doi: 10.1016/j.nlm.2013.12.015. Epub 2014 Jan 11.